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MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
MetabolomicsSNAP25 inhibits glioma progression by regulating synapse plasticity via GLS-mediated glutaminolysis

INTRODUCTION: Neuronal activity regulated by synaptic communication exerts an important role in tumorigenesis and progression in brain tumors. Genes for soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) annotated with the function ‘vesicle’ about syn...

2021-08-12 | MTBLS2806 | MetaboLights
TranscriptomicsAn array based analysis of miRNA expression comparing matched frozen and FFPE human tissue samples
MicroRNAs (miRNAs) are small non-coding RNAs that repress gene expression at the post transcriptional level via an antisense RNA-RNA interaction. Generally, miRNAs derived from snap frozen or fresh samples are used for array based profiling. Since tissues in most pathology departments are available ...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-12458 | biostudies-arrayexpress
MetabolomicsLow-temperature induced neuro-oxidative stress and metabolic reprogramming in the brain of juvenile fourfinger threadfin (Eleutheronema tetradactylum)
This study investigated the effects of low-temperature stress on the brain metabolome of juvenile fourfinger threadfin (Eleutheronema tetradactylum). Using UHPLC-Q-TOF-MS-based untargeted metabolomics, we analyzed brain tissues from fish exposed to 28°C (control) and 18°C for 7 and 14 days. The aim ...
2026-07-22 | MTBLS15103 | MetaboLights
MetabolomicsSpatial metabolomics shows contrasting phosphonolipid distributions in tissues of marine bivalves

Lipids are an integral part of cellular membranes, vary between species, and allow cells to alter stiffness, permeability and curvature. Among lipids, phosphonolipids uniquely contain a phosphonate bond between carbon and phosphorous. Despite this distinctive biochemical characteristic, few model...

2022-06-26 | MTBLS2960 | MetaboLights
UnknownSuccessful ATAC-Seq From Snap-Frozen Equine Tissues.
Not available
S-EPMC8242358 | biostudies-literature
ProteomicsComparative proteome stability analysis of snap frozen, RNAlater preserved, and formalin-fixed paraffin-embedded human colon mucosal biopsies
Clinical proteomics research is in part limited by the availability of clinical samples. However, large biobanks exist worldwide containing formalin-fixed and paraffin embedded samples and samples stored in RNAlater. The extraction of proteins for proteome analysis from samples prepared by either me...
ORGANISM(S): Homo sapiens (Human) 
2015-11-23 | PXD002029 | Pride
Human Snap-frozen Proteomics Mucosa Lc-ms Ffpe Rnalater Colon Stability 
TranscriptomicsThe impact of collection and storage of lung tumour tissue on whole genome expression profiling
We set out to investigate systematic changes in gene expression that may occur between surgical resection, routine processing in the histopathology department, frozen storage, and long term archiving in FFPE blocks. Lung carcinoma tissue samples were obtained from six patients during tumour resectio...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-MTAB-581 | biostudies-arrayexpress
TranscriptomicsmiRNA degradation in frozen tissue
To determine the effect of RNA degradation on miRNA expression profiling. To mimic total RNA degradation in snap-frozen livers and duodenums from mice (wild type female, C57/Bl6) tissues were stored in a -80°C freezer and then transferred to dry ice. Each frozen tissue was sliced into five identica...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-19104 | biostudies-arrayexpress
TranscriptomicsStudy for evaluating the effect of cold ischemic time and RNA stabilization method on RNA integrity and gene expression measurements
Time series of eleven breast cancer samples subjected to different cold ischemic stress of up to 3 hr post tumor excision. A different 2x2 factorial within this study evaluated the effect of stabilization method (RNAlater vs snap freezing) and stablization delay (0 and 40 min) at room temperature. T...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-25011 | biostudies-arrayexpress
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