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ProteomicsSNX10 regulates the clearance of mitochondrial proteins and mitochondrial bioenergetics
We here show that SNX10 localizes to endocytic compartments in a PtdIns3P-dependent manner and that mutations in the PX domain associated with autosomal recessive osteopetrosis prevent its endosomal recruitment. We demonstrate that SNX10 regulates endosomal trafficking but also interacts with mitoch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056720 | Pride
Mitochondrial homeostasis Autophagy Mitophagy Mitochondria Endosomes Snx10 Endocytosis 
ProteomicsMass spectrometry analysis for IP with SNX10 Antibody in CRC HCT-8 cell
SNX10-HA overexpression was performed in CRC HCT-8 cells. Cells were then infected with HCoV-OC43 or control virus fluid. The protein interacted with SNX10 were analyzed by mass spectrometry. The SNX10 overexpressed and control cells in the logarithmic growth phase were collected for IP with HA-Tag...
ORGANISM(S): Homo Sapiens 
2025-03-17 | PXD061906 |
ProteomicsSNX10 regulates the proliferation, apoptosis and cell cycle of acute B lymphoblastic leukemia cells via the PI3K/Akt signaling pathway
B-cell acute lymphoblastic leukemia (B-ALL) is a type of acute lymphoblastic leukemia that originates from B cells. It typically occurs in children and adolescents, but it can also appear in adults. Sorting nexin 10 (SNX10) has recently been identified as a significant regulatory factor in various t...
ORGANISM(S): Homo Sapiens 
2025-03-14 | PXD061830 |
TranscriptomicsSNX10 deficiency confers resistance to anti-HER2 antibody-drug conjugates via regulating endosomal trafficking
Antibody-drug conjugates (ADCs) are a rapidly developing therapeutic approach in cancer treatment that has shown remarkable efficacy in breast cancer. Despite the promising efficacy of anti-HER2 ADCs, many patients are still experiencing disease progression under treatment. Here, by analyzing the tr...
ORGANISM(S): Homo sapiens 
2025-03-31 | GSE269495 | GEO
UnknownAn SNX10-dependent mechanism downregulates fusion between mature osteoclasts.
Not available
S-EPMC8182410 | biostudies-literature
UnknownFKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts.
Not available
S-EPMC6570537 | biostudies-literature
UnknownSNX10 functions as a modulator of piecemeal mitophagy and mitochondrial bioenergetics.
Not available
S-EPMC11893173 | biostudies-literature
Unknownα-hederin decreases the glycolysis level in intestinal epithelial cells via SNX10-mediated DEPDC5 degradation.
Not available
S-EPMC12756552 | biostudies-literature
UnknownSNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection.
Not available
S-EPMC5589552 | biostudies-literature
UnknownGenome sequencing identifies a large non-coding region deletion of SNX10 causing autosomal recessive osteopetrosis.
Not available
S-EPMC10040338 | biostudies-literature
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