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ProteomicsSIMPLEX a multimolecular omics approach for systems biology
We introduce here SIMPLEX (SImultaneous Metabolite, Protein, Lipid EXtraction procedure), a unique strategy for the quantitative investigation of lipids, metabolites and proteins. SIMPLEX offers a fundamental turn in study design since multimolecular classes can be accessed in parallel from one samp...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-08 | PXD002101 | Pride
Pparg signaling Metabolites Proteomics Lipidomics 
ProteomicsCyclin Y is expressed in platelets and modulates integrin outside-in signaling
Diabetes is associated with platelet hyperactivation and enhanced risk of thrombosis development. We have previously shown that calpain inhibition stabilizes the platelet proteome in diabetic patients. However, a global proteome analysis comparing platelets from healthy donors and from diabetic pati...
ORGANISM(S): Homo sapiens (Human) 
2021-05-31 | PXD021271 | Pride
Proteomics Platelets Diabetes 
ProteomicsEndothelial regulation of platelet activation and signaling: endothelial effects on the platelet phosphoproteome
The endothelial regulation of platelet activity is incompletely understood. We investigated how the presence of human umbilical vein endothelial cells (HUVEC) in whole-blood microfluidics affected platelet activation induced by collagen receptor glycoprotein VI (GPVI) and the PAR receptors for throm...
ORGANISM(S): Homo sapiens (Human) 
2026-09-08 | PXD047399 | Pride
Phosphoproteomcis Platelets 
ProteomicsAdipose tissue-derived microRNAs as epigenetic modulators of type 2 diabetes
White adipose tissue (WAT) dysfunction along with an aberrant expression of miRNAs are strongly associated with the risk of developing type 2 diabetes (T2D) with limited evidence linking early changes in the WAT-derived miRNAs and T2D. The present study aims to identify early miRNome changes prognos...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-15 | PXD057291 | Pride
Proteomics Adipose tissue Data indipendent acquistion Diabetes 
ProteomicsCombined assessment of global proteome, phosphoproteome and N-terminal protein cleavage to characterize altered platelet functions in human Scott syndrome
The Scott syndrome is a rare bleeding disorder associated with a mutation in the gene encoding anoctamin-6 (TMEM16F). After stimulation of Ca2+-mobilizing agonists, syndromatic platelets show a reduced phosphatidylserine exposure and do not form membrane blebs. Given the central role of anoctamin-6 ...
ORGANISM(S): Homo sapiens (Human) 
2016-08-24 | PXD002883 | Pride
Phosphoproteome Human platelets N-terminal chafradic Lc-ms Proteome 
ProteomicsControl of the mitochondrial carrier import pathway by DYRK1A
Mitochondria require a complete and functional proteome to maintain a plethora of metabolic reactions in a cell. Changes in cellular demands depend on a rapid adaptation of the mitochondrial proteome. The translocase of the outer membrane TOM, constitutes the organellar entry gate that imports nearl...
ORGANISM(S): Homo sapiens (Human) 
2021-05-31 | PXD019520 | Pride
Tom70 Mitochondria Phosphoproteomics 
ProteomicsArabidopsis thaliana N-terminal proteome,LC-MS
An extended ChaFRADIC workflow was applied to analyze the N-terminal proteome of Arabidopsis thaliana seedlings. Using iTRAQ protein labeling, a multi-enzyme digestion approach including trypsin, GluC, and subtilisin, a total of 200 μg per enzyme were used, and only 1/3 of each ChaFRADIC-enriched fr...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-07-21 | PXD001855 | Pride
Arabidopsis thaliana Chafradic Itraq reagent Enrichment of n-terminal peptide 
ProteomicsImpaired iloprost-induced platelet inhibition and phosphoproteome changes in patients with confirmed pseudohypoparathyroidism type Ia, linked to genetic mutations in GNAS
Patients diagnosed with pseudohypoparathyroidism type Ia (PHP Ia) suffer from hormonal resistance. This is often accompanied by abnormal postural and facial features, brachydactyly and dermal calcifications, a condition classified as Albright hereditary osteodystrophy (AHO) syndrome. Typically, this...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD016534 | Pride
Human platelets Phosphoproteome Tmt Itraq Proteome Albright hereditary osteodystrophy 
ProteomicsMild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation: exploration of platelet proteome and lipidome.
Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Trillions of people worldwide display mildly elevated levels of plasma lipids and cholesterol due to diet and life-style. The relationship between severe hyperlipidemia and thrombosis has been extensively investigated, but...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-08 | PXD020276 | Pride
Proteomics Platelet activation Thrombus formation Coagulation Hyperlipidemia Mouse platelets 
ProteomicsFunctional class assignment of the complete platelet proteome and transcriptome
Advances in platelet transcriptomics allow prediction of the full human platelet proteome. We integrated proteomes from six cohorts, encompassing 5.2k unique proteins (3.5k with copy numbers), with novel genome-wide platelet and megakaryocyte transcriptomes (Blueprint).
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022011 | Pride
Proteomics Human platelets Transcriptomics 
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