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MetabolomicsGREM1 Deficiency induced Bone Marrow Adipose Niche promotes B-cell Acute Lymphoblastic Leukemia Disease Progression
Relapse and disease progression are the primary causes of treatment failure and subsequent mortality in children B-cell acute lymphocytic leukemia (B-ALL). At diagnosis and during treatment, the bone marrow adipose microenvironment is commonly observed in pediatric leukemia. However, the relationshi...
2024-09-23 | MTBLS10103 | MetaboLights
TranscriptomicsTranscription profiling of mouseWT vs CD137L-/- GC B cells
WT and CD137L-/- mice of 8-12 weeks old were immunized intra-peritoneally with 50 µg chicken gamma- globulin conjugated to 4-hydroxy-3-nitrophenylacetyl (NP-CG) in alum or infected intranasally with 25 hemagglutinin units of influenza virus strain A/NT/60/68 in 50 µl HBSS. Nine days after immuniza...
ORGANISM(S): Mus musculus 
2009-07-24 | E-NCMF-29 | biostudies-arrayexpress
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp1]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067271 | Pride
Pre-b B-cell 
UnknownThe complete mitochondrial genome sequence and annotation of Tylopilus plumbeoviolaceoides T.H. Li, B. Song & Y.H. Shen, 2002 (Boletaceae, Boletoideae).
Not available
S-EPMC9225691 | biostudies-literature
GenomicsDNA Cytosine Hydroxymethylation Levels Are Distinct Among Peripheral Blood Leukocytes
Peripheral blood leukocytes are the most commonly used surrogates to study epigenome-induced risk and epigenomic response to disease related stress. We considered the hypothesis that the TET enzyme catalyzed hydroxymethylation of 5mC to 5hmC might vary among peripheral blood leukocytes and reflect t...
ORGANISM(S): Homo sapiens 
2016-07-05 | E-GEOD-70519 | biostudies-arrayexpress
ProteomicsBeta-catenin interacting proteins in BCR-ABL1+ B-ALL cells [exp2]
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in BCR-ABL1 transformed murine pre-B cells with induced beta-catenin activation via CTNNB1 exon3 fl/fl + Cre.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067314 | Pride
B-all 
TranscriptomicsEpigenetic targeting of activation-induced cytidine deaminase
Precisely how AID is recruited to these off-target sites is not entirely understood. To gain further insight into how AID selects its targets we compared AID-mediated translocations in two different cell types, B cells and mouse embryonic fibroblasts (MEFs). AID targets a distinct set of hotspots in...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-61523 | biostudies-arrayexpress
ProteomicsBeta-catenin interacting proteins in WT and Ikzf1/3-KO BCR-ABL1 transformed B-ALL
Identification of beta-catenin interacting proteins via affinity purification with anti-beta-catenin antibody or IgG control in WT (NTC control) or Ikzf1/Ikzf3-KO (dual CRISPR KO) BCR-ABL1 transformed murine pre-B cells with CTNNB1 activation via a Ctnnb1 Ex3 fl/fl + Ert2Cre model.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-13 | PXD067318 | Pride
Pre-b B-cell 
TranscriptomicsCombined loss of Tet1 and Tet2 promotes B-cell, but not myeloid malignancies in mice
TET1/2/3 are methylcytosine dioxygenases regulating cytosine hydroxymethylation in the genome. Tet1 and Tet2 are abundantly expressed in HSC/HPCs and implicated in the pathogenesis of hematological malignancies. Tet2-deletion in mice causes myeloid malignancies, while Tet1-null mice develop B-cell l...
ORGANISM(S): Mus musculus 
2015-11-12 | E-GEOD-73611 | biostudies-arrayexpress
GenomicsGenome-wide maps of chromatin state in HSC, Pro B and mature B cells
We have used a genome-wide ChIP-sequencing approach to define and investigate the dynamics of the cis-regulatory landscape in three developmental stages of the murine hematopoietic system. To this end, we have compared the profiles of H3K4me3, H3K4me1, H3K27ac, H3K27me3 and H3K9me2 in HSCs, committe...
ORGANISM(S): Mus musculus 
2015-10-19 | E-GEOD-60005 | biostudies-arrayexpress
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