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TranscriptomicsListeria monocytogenes SOS response determined after mitomycin C exposure
The SOS response is a conserved pathway that is activated under certain stress conditions and is regulated by the repressor LexA and the activator RecA. The food-borne pathogen Listeria monocytogenes contains RecA and LexA homologs, but their roles in Listeria have not been established. In this stud...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-05-19 | E-GEOD-12634 | biostudies-arrayexpress
TranscriptomicsMode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resista...
ORGANISM(S): Staphylococcus aureus 
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
no omics definedTranscription profiling time series of Pseudomonas aeruginosa wild type and lexA mutant response to treatment with ciprofloxacin
Pseudomonas aeruginosa infections can be virtually impossible to eradicate and the evolution of resistance during antibiotic therapy is a significant concern. In this study, we use DNA microarrays to characterize the global transcriptional response of P. aeruginosa to clinical-like doses of the ant...
ORGANISM(S): Pseudomonas aeruginosa 
2007-09-21 | E-GEOD-5443 | biostudies-arrayexpress
ProteomicsSOS Genes Are Rapidly Induced While Mutagenesis Is Temporally Regulated by Changes in Protein Activation and Nucleotide Pools After a Sub-lethal Dose of Ciprofloxacin in Escherichia coli
The DNA damage inducible SOS response in bacteria serves to increase survival of the species. The SOS response first initiates error-free repair which is followed by error-prone repair. Here, we have employed a multi-omics approach to elucidate the temporal coordination of the SOS response using tra...
ORGANISM(S): Escherichia coli 
2024-03-26 | PXD047394 | Pride
Signalomics Escherichia coli Ciprofloxacin Sos response 
no omics definedTranscription profiling of Listeria monocytogenes EGD-e after heat-shock for 3, 10, 20, and 40 min
L. monocytogenes EGD-e (Glaser et al., 2001) was grown in Brain Hearth Infusion Broth (Difco) with shaking (200 rpm, New Brunswick C24KC) using 10 ml culture medium in 100 ml conical flasks. An exponentially growing culture was used to inoculate 100 ml of fresh pre-warmed BHI broth in a 500 ml flask...
ORGANISM(S): Listeria monocytogenes 
2007-10-09 | E-MEXP-1118 | biostudies-arrayexpress
TranscriptomicsThe SOS response controls intrinsic resistance to cephalosporins
Comparison of the transcription profile between Enterococcus faecalis V583 strain and its mutant having a constitutive SOS response
ORGANISM(S): Enterococcus faecalis 
2017-07-05 | E-MEXP-3861 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchioloalveolar lavage (BAL) not used for diagnostic purposes taken from patients with LF syndrome and SOS of stage II active disease
Cells from bronchioloalveolar lavage (BAL) not used for diagnostic purpose were taken from patients with LF syndrome and SOS of stage II active disease. The SOS samples were divided in two groups by the means of CD4+-/CD8+-cell ratio < 5 or > 5, respectively. At least five samples of each group were...
ORGANISM(S): Homo sapiens 
2007-04-25 | E-RZPD-23 | biostudies-arrayexpress
TranscriptomicsExpression data from Escherichia coli after treatment with nalidixic acid (NA)
Having found that LexA degradation was significantly higher under apoptotic like death (ALD) than under SOS conditions, we hypothesized that additional genes tightly regulated by LexA would be transcribed under ALD conditions. We used microarray analysis to test the transcription pattern of up-regul...
ORGANISM(S): Escherichia coli 
2014-03-27 | E-GEOD-56251 | biostudies-arrayexpress
TranscriptomicsAltering gene expression by aminocoumarin (novobiocin) treatment: Role of DNA supercoiling in Staphylococcus aureus
For Staphylococcus aureus it was shown previously that aminocoumarinecoumarin antibiotics such as novobiocin lead to immediate down-regulation of recA expression and thereby inhibition of the SOS response, the mutation frequency and the recombination capacity. Aminocoumarinecoumarin function by inh...
ORGANISM(S): Staphylococcus aureus 
2014-09-08 | E-GEOD-50157 | biostudies-arrayexpress
Transcriptomicstomato salt response
Wild halophytic tomato has long been considered as an ideal gene donor for improving salt tolerance in tomato cultivars. Here, a wild tomato genotype, Solanum pimpinellifolium M-bM-^@M-^XPI365967M-bM-^@M-^Y is significantly more salt-tolerant than a cultivar, Solanum lycopersicom M-bM-^@M-^Xmoneymak...
ORGANISM(S): Solanum lycopersicum 
2010-05-31 | E-GEOD-16401 | biostudies-arrayexpress
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