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ProteomicsNew insights on sperm function in male infertility of unknown origin: proteomics characterization
The global trend on (male)infertility is concerning and the unidentifiable causes in half of the cases demands a better understanding of the molecular, biochemical and metabolic mechanisms as well as the identification of external and internal factors operating behind it, that might help to explain ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD040292 | Pride
Xxxxxxidiopathic male infertility  unexplained male infertility  sperm function  sperm proteomics 
ProteomicsCells responding to bacterial pore-forming toxins release extracellular vesicles displaying similar proteomic content
The plasma membrane (PM) protects cells from extracellular threats and supports cellular homeostasis. Some pathogens produce pore-forming toxins (PFTs) that disrupt PM integrity by forming transmembrane pores. High PFT concentrations cause massive damage leading to cell death and facilitating infect...
ORGANISM(S): Homo sapiens (Human) 
2023-02-10 | PXD037166 | Pride
Calcium influx Shedding Extracellular vesicles Hela Listeriolysin o Label-free Pneumolysin Q exactive Pore-forming toxins Plasma membrane repair 
TranscriptomicsIn vivo transcriptome of Listeria monocytogenes EGDe
Time course study of the mouse infection by comparing the genomic transcriptional patterns of Listeria monocytogenes EGDe grown under laboratory conditions (exponential growth phase) with that of in vivo-grown bacteria (in mouse spleens) over three days of infection. Time course study of the mouse i...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-06-25 | E-GEOD-13057 | biostudies-arrayexpress
TranscriptomicsPyrus communis: 'Ercolini' cultivar vs. 'Rocha' cultivar
Transcriptional profiling of pear tree comparing a resistant/tolerant cultivar with a susceptible cultivar to the Stemphylium vesicarium fungus Rocha' pear is an economically important portuguese Pyrus communis L. cultivar very susceptible to the Stemphylium vesicarium pathogenic fungus, the brown s...
ORGANISM(S): Pyrus communis 
2011-07-02 | E-GEOD-30353 | biostudies-arrayexpress
TranscriptomicsTrancriptome analysis of peripheral leukocytes from SARS-CoV-2 infected patients and healthy uninfected individuals during the first wave of COVID-19 pandemic in Brazil
To evaluate the gene expression profiling of peripheral leukocytes in different outcomes of SARS-CoV-2 infections, whole blood samples were collected from individuals with positive SARS-CoV-2 nasopharyngeal swab by RT-PCR (54 patients) and healthy uninfected individuals (12 volunteers). Infected pat...
ORGANISM(S): Homo sapiens 
2022-04-29 | E-MTAB-11240 | biostudies-arrayexpress
ProteomicsChronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system
It remains unknown why upon similar acute/subacute painful conditions, pain persists in some individuals while in others it resolves. Genetic factors, mood, and functional alterations, particularly involving the mesolimbic network, appear to be key. In order to explore potential susceptibility/resis...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-27 | PXD022478 | Pride
Neuropathic pain  allodynia  proteomic screening  nucleus accumbens  resistance  proteasome 
TranscriptomicsTranscriptomic profiling of choroid plexus in experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is a demyelinating disease causing major neurological disability in young adults. We characterized the transcriptome of the choroid plexus (CP), which is part of the blood-brain barriers and the major site of cerebrospinal fluid (CSF) production, in the experimental autoimmun...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-35363 | biostudies-arrayexpress
UnknownEvaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries.
Not available
S-EPMC10771257 | biostudies-literature
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