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MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
TranscriptomicsB1 sox (sox2/3/19a/19b) quadruple knockdown in the zebrafish embryo
The B1 SOX transcription factors SOX1/2/3/19 have been implicated in various processes of early embryogenesis. However, their regulatory functions in stages from the blastula to early neurula remain largely unknown, primarily because loss-of-function studies have not been informative to date. In our...
ORGANISM(S): Danio rerio 
2009-12-31 | E-GEOD-18830 | biostudies-arrayexpress
ProteomicsPiwil-2 is associated with advanced tumor stage and poor outcome in Merkel cell carcinomas
Merkel cell carcinomas (MCCs) are rare, highly aggressive skin cancers with poor outcome due to early lymphatic tumor spread and frequent recurrences. MCCs mostly occur in the head and neck and are mainly caused by an infection with the Merkel cell polyomavirus (MCPyV). Increasing evidence suggests ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD059625 | Pride
Sox-2 Mcpyv Merkel cell carcinoma Piwil-2 Pirna 
UnknownIdentification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex.
Not available
S-EPMC135755 | biostudies-literature
no omics definedTranscription profiling of human mesenchymal stem cells transfected with adenoviruses carrying the SOX trio or LacZ control to identify target molecules
The aim of the experiment is to identify target molecules of the SOX trio (SOX9, SOX5 and SOX6). hMSC were transfected with the adenoviruses carrying the SOX trio or the LacZ-control, and total RNA was isolated after 2 weeks of culture.
ORGANISM(S): Homo sapiens 
2007-04-01 | E-MEXP-960 | biostudies-arrayexpress
UnknownSox-2 Positive Neural Progenitors in the Primate Striatum Undergo Dynamic Changes after Dopamine Denervation.
Not available
S-EPMC3688912 | biostudies-literature
TranscriptomicsCaveolin-1 and Sox-2 are Predictive Biomarkers of Cetuximab Response in Head and Neck Cancer
Expression analysis (RNA-seq) and RPPA data (see publication) of head and neck cancer patient-derived xenographs (PDXs) revealed Sox-2 and Cav-1 expression to be biomarker determinants of head and neck cancer patient tumor response to cetuximab (EGFR inhibitor) treatment.
ORGANISM(S): Homo sapiens 
2021-10-12 | GSE183881 | GEO
UnknownImmunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.
Not available
S-EPMC9841912 | biostudies-literature
TranscriptomicsGene expression analysis during reprogramming with sequential infecion of Oct4/Klf4/cMyc/Sox2
To further understand the mechanism of reprogramming, the mouse embryonic fibroblast cells were infected with Oct4, Klf4, c-Myc and Sox2 with special sequence. 1) Oct4 and Klf4 containing retrovirus was delivered on day 0. 2) Oct4, Klf4 and c-Myc were delivered on Day 1.5. 3) c-Myc and Sox-2 were de...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-39260 | biostudies-arrayexpress
GenomicsCaveolin-1 and Sox-2 are Predictive Biomarkers of Cetuximab Response in Head and Neck Cancer
Caveolin-1 and Sox-2 are Predictive Biomarkers of Cetuximab Response in Head and Neck Cancer
PRJNA762273 | ENA
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