Sort   by:  
 Page size 
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells
This SuperSeries is composed of the following subset Series: GSE34904: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1) GSE34912: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2) GSE34918: NANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34921 | biostudies-arrayexpress
ProteomicsDevelopment of a method for quantitative analysis of in vivo interactions of pluripotency transcription factors Sox2, Oct4, Nanog by mass spectrometry
Protein-protein proximity of core pluripotency transcription factors plays an important role during cell reprogramming. Pluripotent embryonic stem (ES) cell identity is controlled by a trio of transcription factors: Sox2, Oct4, and Nanog. These proteins often bind to closely localized genomic sites....
ORGANISM(S): Homo sapiens (Human) 
2020-01-21 | PXD015756 | Pride
Mass spectrometry Oct4 Proximity utilizing biotinylation Transcription factors Sox2 Pluripotency 
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 4)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34920 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 3)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34918 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 1)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34904 | biostudies-arrayexpress
TranscriptomicsNANOG-OCT4-SOX2 Regulatory Module in Human Embryonic Stem Cells (dataset 2)
The transcription factors Nanog, Oct4 and Sox2 are the master regulators of pluripotency in mouse embryonic stem cells (mESCs), however, their functions in human ESCs (hESCs) have not been rigorously defined. Here we show that the requirements for NANOG, OCT4 and SOX2 in hESCs differ from those in ...
ORGANISM(S): Homo sapiens 
2012-04-05 | E-GEOD-34912 | biostudies-arrayexpress
GenomicsGenome-wide maps of Sox/Oct partnerships pluripotent and lineage-committed cells
We show here by using genome-wide ChIP-sequencing that lineage segregation involves multiple Sox/Oct partnership. In undifferentiated ES cells Oct4 interacts with Sox2 and both TFs bind on the 'canonical' motif, whereas in cells commited to PrE lineage Oct4 switches from Sox2 to Sox17 interaction an...
ORGANISM(S): Mus musculus 
2013-04-23 | E-GEOD-43275 | biostudies-arrayexpress
TranscriptomicsGeneration of human induced pluripotent stem cells from mesenchymal cells of gut mesentery by Oct4/Sox2/Nanog
Background and aim: Human Induced pluripotent stem (iPS) cells have been derived from dermal fibroblasts, keratinocytes and blood cells by ectopic expression of defined transcription factors.1–5 Application of this approach in human cells would have enormous potential and generate patient-specific pl...
ORGANISM(S): Homo sapiens 
2009-09-26 | E-GEOD-18180 | biostudies-arrayexpress
ProteomicsCopper depletion modulates OXPHOS in SOX2/OCT4+ cancer cells to impair triple negative breast cancer metastasis.
Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been associated with a significant survival benefit in high-risk triple negative breast cancer (TNBC) patients. Despite these...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-10-26 | PXD027089 | Pride
Metabolism Mitochondria Copper Oxphos Ampk Sox2/oct4+ cells Metastasis Triple negative breast cancer Tetrathiomolybdate 
TranscriptomicsTranscription profiling of mouse iPS cells from neural stem cells by 2 factors (Oct4, KLF4) (Kim, Zaehres et al.)
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility to generate patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripo...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-10806 | biostudies-arrayexpress
Sort   by:  
 Page size