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TranscriptomicsMacrophage-specific gene functions in Spi1-directed innate immunity
The Spi1/ Pu.1 transcription factor plays a crucial role in myeloid cell development across many species. Several Spi1 target genes have been identified so far, yet the Spi1-dependent gene group remains largely unknown. To identify novel genes downstream of Spi1 we employed a microarray strategy usi...
ORGANISM(S): Danio rerio 
2010-04-30 | E-GEOD-19206 | biostudies-arrayexpress
TranscriptomicsZebrafish 27hpf embryos: hdac1 mutant (hi1618) vs sibling
Transcriptional profiling of hdac1 mutant zebrafish in comparison to their sibling embryos. Embryos resulting from a cross between heterozygous hdac1 mutant zebrafish (hi1618/+) where cultured together then mutants separated from the siblings one the basis of phenotype and RNA extracted from the tw...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26707 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos: hdac1 Morphants vs Standard control morphants at 12, 18 and 27 hpf
Transcriptional profiling of hdac1 ATG morphant zebrafish embryos in comparison to standard control injected embryos. Embryos where injected at the one cell stage with either a translation blocking morpholino (Hdac1 ATG) or Standard control morpholino (StCo). RNA was extracted at 12, 18 and 27hpf ...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26709 | biostudies-arrayexpress
TranscriptomicsZebrafish embryos: hdac1 Morphants vs Standard control morphants
Transcriptional profiling of hdac1 morphant zebrafish embryos in comparison to standard control injected embryos. Embryos where injected at the one cell stage with either a translation blocking morpholino (Hdac1 ATG), splice blocking morpholino (Hdac1 Splice) or Hdac1 mismatch control morpholino (H...
ORGANISM(S): Danio rerio 
2011-01-21 | E-GEOD-26708 | biostudies-arrayexpress
TranscriptomicsSalmonella typhimurium infection of zebrafish embryo
Characterization of the zebrafish embryonic host response to systemic bacterial infection with Salmonella typhimurium wild type strain (SL1027) and its isogenic LPS O-antigen mutant Ra (SF1592) by means of a time-resolved global expression analysis. All infection experiments were performed using mix...
ORGANISM(S): Danio rerio 
2010-05-22 | E-GEOD-13994 | biostudies-arrayexpress
TranscriptomicsSpecificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection
Pathogenic mycobacteria have the ability to survive within macrophages and persist inside granulomas composed of host immune cells. The complex host-pathogen interactions that determine the outcome of a mycobacterial infection process result in marked alterations of the host gene expression profile....
ORGANISM(S): Danio rerio 
2010-05-15 | E-GEOD-15328 | biostudies-arrayexpress
TranscriptomicsMycobacterium marinum chronic infection of adult zebrafish
Novel high-throughput deep sequencing technology has dramatically changed the way that the functional complexity of transcriptomes can be studied. Here we report on the first use of this technology to gain insight into the wide range of transcriptional alterations that are associated with an infecti...
ORGANISM(S): Danio rerio 
2009-06-29 | E-GEOD-14782 | biostudies-arrayexpress
TranscriptomicsMacrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish
Macrophage expressed gene 1 (MPEG1) encodes an evolutionary conserved protein with a predicted Membrane Attack Complex/Perforin domain associated with host defence against invading pathogens. In vertebrates, MPEG1 is an integral membrane protein of macrophages, but how it contributes to the macropha...
ORGANISM(S): Danio rerio 
2014-09-01 | E-GEOD-54885 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory and lethal infection in zebrafish embryos. To characterize the embryonic innate host response at the transcriptome level, we have extended and validated previous microarray data by Illumina next-generation sequen...
ORGANISM(S): Danio rerio 
2010-10-25 | E-GEOD-22472 | biostudies-arrayexpress
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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