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TranscriptomicsGeneration of clinical grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of B-cell malignancies
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures to generate relevant numbers of this T cell population are undefined...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-68003 | biostudies-arrayexpress
UnknownAn open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences.
Not available
S-EPMC10291816 | biostudies-literature
TranscriptomicsTranscription profiling of mouse tet inducible NIH 3T3 cells expressing ATPase-defective BRG-1 to identify SWI-SNF-Regulated Genes
NIH 3T3 cells (mouse fibroblasts) were engineered such that the dominant negative ATPase-defective BRG-1 is expressed via the tet-off inducible expression system to inactivate the SWI-SNF chromatin remodeling complexes (Mol Cell Biol 20, 2839). These cell lines have been used for several studies to ...
ORGANISM(S): Mus musculus 
2006-01-01 | E-MEXP-434 | biostudies-arrayexpress
UnknownEndocrine modulation of cortical and retinal baseline perfusion across the menstrual cycle.
Not available
S-EPMC12913051 | biostudies-literature
UnknownTracking blobs in the turbulent edge plasma of a tokamak fusion device.
Not available
S-EPMC9616937 | biostudies-literature
UnknownDomino-like transient dynamics at seizure onset in epilepsy.
Not available
S-EPMC7544071 | biostudies-literature
UnknownAssessment of DNA methylation profiling and copy number variation as indications of clonal relationship in ipsilateral and contralateral breast cancers to distinguish recurrent breast cancer from a second primary tumour.
Not available
S-EPMC4600279 | biostudies-literature
ProteomicsMudPIT analyses of proteins associated with Piccolo and Bassoon in the presynaptic active zone
We used a 3-step protocol that separates lipid-associated proteins based on their buoyant density, size and charge. All steps were conducted either on ice or at 4C. Step 1 involved a sucrose density gradient centrifugation in which ca. 100 postnatal day 4 rat brains were homogenized in buffer A (5...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-07-11 | MSV000079897 | MassIVE
TranscriptomicsHeterochromatin protein 1 secures survival and transmission of malaria parasites
The malaria parasite Plasmodium falciparum relies on clonally variant gene expression in order to escape immune recognition and secure continuous proliferation during blood stage infection. Here, we studied the role of heterochromatin protein 1 (HP1), an evolutionary conserved regulator of heritable...
ORGANISM(S): Plasmodium falciparum 3D7 
2014-07-09 | E-GEOD-53176 | biostudies-arrayexpress
ProteomicsKDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism
Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals with intellectual disability (ID). To understand the link between KDM5 and ID, we generated five Drosophila strains harboring missense alleles analogous to those observed in patients. These alleles showed effec...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-11-14 | PXD046963 | Pride
Ribosome Neuron Kdm5 Brain Ipscs Translation Transcription Kdm5c Histone demethylase Ribo-seq 
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