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GenomicsGenome-wide maps of KDM5 binding in drosophila adults
To determine which genes affected by loss of KDM5 in adults were direct targets, we carried out KDM5 ChIP-seq analyses. To valide this data, we utilized a previously generated fly strain in which the sole source of KDM5 is from a transgene expressing an HA tagged form of KDM5 expressed under the co...
ORGANISM(S): Drosophila melanogaster 
2015-12-22 | E-GEOD-70589 | biostudies-arrayexpress
TranscriptomicsRNA-seq analyses of kdm5 mutant flies and wt flies under normal condition and oxidative stress
Comparing the transcriptome of wildtype and kdm5 mutant flies in normal conditions revealed a total of 4787 genes that were significantly downregulated and thus require KDM5 for their activation, and 3269 upregulated genes that are normally repressed by KDM5 (p<0.05, FDR <0.05). Because kdm5 mutant...
ORGANISM(S): Drosophila melanogaster 
2015-12-22 | E-GEOD-70590 | biostudies-arrayexpress
GenomicsH3K4me3 ChIP in multiple myeloma MM1S cells in the presence and absence of KDM5-C70
In this experiment we demonstrate the use of an inhibitor of the KDM5 family of histone demethylases, KDM5-C70, on H3K4me3 marks in the multiple myeloma cell line MM1S. KDM5-C70 increases H3K4me3 in a global fashion across the genome. Examination of H3K4me3 mark across MM1S cells treated with eithe...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-78206 | biostudies-arrayexpress
TranscriptomicsRNA-seq of HER2-positive breast cancer BT474 cell line in response to KDM5 ihibition
Alterations in the histone methylation profiles are observed in various types of cancer and targeting of this epigenetic process has therapeutic potential. Here we provide proof-of-principle that pharmacological targeting of KDM5 histone-demethylases is a new strategy for the personalized treatment ...
ORGANISM(S): Homo sapiens 
2019-02-01 | E-MTAB-7433 | biostudies-arrayexpress
ProteomicsKDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism
Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals with intellectual disability (ID). To understand the link between KDM5 and ID, we generated five Drosophila strains harboring missense alleles analogous to those observed in patients. These alleles showed effec...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-11-14 | PXD046963 | Pride
Ribosome Neuron Kdm5 Brain Ipscs Translation Transcription Kdm5c Histone demethylase Ribo-seq 
GenomicsLeuconostoc mesenteroides isolate:KDM5
Leuconostoc mesenteroides isolate:KDM5 Genome sequencing
PRJNA1103340 | ENA
ProteomicsNon-canonical RNA-binding of the histone lysine demethylase KDM5 through interactions with G-quadruplex sequences
RNA-binding proteins are important regulators of RNA biogenesis and function, and recent work shows that chromatin- and RNA-binding proteins can have regulatory roles in transcription. Several approaches have been developed to predict RNA-binding proteins and to identify them experimentally at large...
ORGANISM(S): Homo sapiens (Human) 
2024-04-11 | PXD050767 | Pride
Histone lysine demethylase kdm5  g-quadruplex  non-canonical rna-binding 
ProteomicsBRWD3 targets KDM5/Lid for degradation to maintain H3K4 methylation levels
Histone modifications are critical for regulating chromatin structure and gene expression. Dysregulation of histone modification levels may contribute to disease development and cancer. Therefore, understanding histone modifications is essential for development and disease. The chromatin-binding pro...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-09-19 | PXD039706 | Pride
H3k4 Histone Degradation E3 ubiquitin ligase Brwd3 
GenomicsRNA-seq analysis of de larval ventral nerve cord (VNC) from kdm5[L854F] and enzymatically inactive kdm5[JmjC*]
RNA-seq analysis of de larval ventral nerve cord (VNC) from kdm5[L854F] and enzymatically inactive kdm5[JmjC*]
PRJNA668325 | ENA
GenomicsKDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length [ChIP-Seq]
We discovered that the Saccharomyces cerevisiae lysine demethylase, Jhd2 (also known as KDM5), recruits 3'UTR processing machinery and promotes alteration of 3'UTR length in a demethylase-dependent manner. Interaction of Jhd2 with both chromatin and RNA suggests that Jhd2 affects selection of polyad...
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-23 | E-GEOD-67211 | biostudies-arrayexpress
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