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ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016188 | Pride
Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Crl4ddb1 
ProteomicsThe CDK12-inhibitor CR8 mediates Cyclin K degradation through the CUL4-RBX1-DDB1 E3 ubiquitin ligase
Small molecules have been identified that induce protein-protein interactions between a substrate and a ubiquitin ligase, resulting in targeted protein degradation. Such molecular glue compounds, unlike traditional enzyme inhibitors, act sub-stoichiometrically to catalyse rapid depletion of previous...
ORGANISM(S): Homo sapiens (Human) 
2020-06-10 | PXD016187 | Pride
Crl4 Cr8 Cyclin k Molecular glue Cdk12 Ubiquitin Ddb1 
UnknownArylsulfatase K, a novel lysosomal sulfatase.
Not available
S-EPMC3798471 | biostudies-literature
UnknownThe CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Not available
S-EPMC7486275 | biostudies-literature
TranscriptomicsHistone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables histone gene transcription, DNA replication, DNA repair, and prevents epigenetic silencing. While K56Ac is globally abundant in yeast and flies its presence has been uncertain in mammals. We show here using mas...
ORGANISM(S): Homo sapiens 
2009-02-09 | E-GEOD-14749 | biostudies-arrayexpress
UnknownExploring Racial Differences in Family Expressions of Emotion and Clinician Empathy in ICU Family Meetings.
Not available
S-EPMC12818917 | biostudies-literature
TranscriptomicsmRNA expression profiling in patients with Tetralogy of Fallot and healthy unaffected individuals
Right ventricular mRNA profiles from 22 patients with Tetralogy of Fallot (TOF) and mRNA-seq profiles from the left and right ventricle (LV and RV, respectively) of 4 healthy unaffected individuals (NH) were generated. The total RNA was isolated from the 30 human heart samples using TRIzol. mRNAs we...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-36761 | biostudies-arrayexpress
UnknownThe effect of mindfulness interventions on stress in medical students: A systematic review and meta-analysis.
Not available
S-EPMC10553303 | biostudies-literature
UnknownCarfilzomib prescribing patterns and outcomes for relapsed or refractory multiple myeloma: a real-world analysis.
Not available
S-EPMC11953251 | biostudies-literature
UnknownThe effect of resilience training on resilience and stress in medical students: a systematic review and meta-analysis.
Not available
S-EPMC12771728 | biostudies-literature
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