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MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
ProteomicsT cells and adipocyte IL-17RC control fat innervation and thermogenesis
The sympathetic nervous system innervates peripheral organs to regulate their function and maintain homeostasis, whereas target cells also produce neurotrophic factors to promote sympathetic innervation1,2. The molecular basis of this bi-directional communication is unknown. Here we use thermogenic ...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-02 | PXD017424 | Pride
Tmt based quantitative proteomics Murine brown adipose tissue 
TranscriptomicsExpression data from C2C12 myoblasts transduced with PRDM16 or vector
PRDM16 is a 140 kDa transcriptional coregulatory protein. PRDM16 has been shown to function as a bi-directional switch in brown fat cell fate by stimulating the development of brown fat cells from myf-5 positive myoblastic precursors. We used microarrays to detail the global programme of gene expres...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15895 | biostudies-arrayexpress
TranscriptomicsIdentification of genes characteristic of committed preadipocyte fibroblasts
In order to identify the molecular mechanisms controlling preadipocyte commitment we derived new sublines of Swiss 3T3 fibroblasts with varying potential for adipogenesis. Swiss 2, Swiss 8, Swiss 9, and Swiss 19 differentiate into fat cells while Swiss 3, Swiss 5, and Swiss 22 have a lower propensi...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-19732 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of wild type and PGC-1alpha knock-out liver and skeletal muscle
PGC-1alpha; is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching. We show here that, while hepatocytes lacking PGC-1alpha; are def...
ORGANISM(S): Mus musculus 
2007-04-06 | E-CBIL-22 | biostudies-arrayexpress
ProteomicsMustn1 is a smooth muscle cell-secreted micropeptide that modulates skeletal muscle extracellular matrix composition
We show that Mustn1 (Musculoskeletal embryonic nuclear protein 1, also known as Mustang) is highly expressed in skeletal muscle during the early stages of hindlimb reloading. Mustn1 expression is transiently elevated in mouse and human skeletal muscle in response to intense exercise, resistance exer...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD047169 | Pride
Skeletal muscle Extracellular matrix 
ProteomicsCharacterization of a mitochondria associated phosphocreatine phosphatase in thermogenic adipocytes
Adaptive thermogenesis has attracted much attention because of its ability to raise systemic energy expenditure and counter obesity and diabetes. Recent data have indicated that thermogenic fat cells utilize creatine to stimulate futile substrate cycling, dissipating chemical energy as heat. This mo...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025032 | Pride
Tnap Thermogenesis Obesity Phosphocreatine Adipocyte 
UnknownCombined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Not available
S-EPMC6149542 | biostudies-literature
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
UnknownInnervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.
Not available
S-EPMC6589139 | biostudies-literature
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