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ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based ...
2024-09-02 | BIOMD0000000187 | BioModels
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering ...
2024-09-02 | BIOMD0000000186 | BioModels
ModelsCaydasi2012 - Regulation of Tem1 by the GAP complex in Spindle Position Checkpoint - Ubiquitous inactive model
Regulation of Tem1 by the GAP complex in Spindle Position Checkpoint - Ubiquitous inactive This model is described in the article: A dynamical model of the spindle position checkpoint. Caydasi AK, Lohel M, Grünert G, Dittrich P, Pereira G, Ibrahim B. Mol. Syst. Biol. 2012; 8: ...
2024-09-02 | BIOMD0000000702 | BioModels
ModelsCaydasi2012 - Inhibition of Tem1 by the GAP complex in Spindle Position Checkpoint
This model is from the article: A dynamical model of the spindle position checkpoint Ayse Koca Caydasi, Maiko Lohel, Gerd Grünert, Peter Dittrich, Gislene Pereira, Bashar Ibrahim Molecular Systems Biology 2012; 582 doi: 10.1038/msb.2012.15 ...
2024-09-02 | BIOMD0000000701 | BioModels
ModelsCaydasi2012 - Regulation of Tem1 by the GAP complex in spindle position cell cycle checkpoint - Ubiquitous association model
Caydasi2012 - Regulation of Tem1 by the GAP complex in spindle position cell cycle checkpoint - Ubiquitous association model This model is described in the article: A dynamical model of the spindle position checkpoint. Caydasi AK, Lohel M, Grünert G, Dittrich P, Pereira G, Ibrah...
2024-09-02 | BIOMD0000000699 | BioModels
ProteomicsNon-canonical functions of spindle checkpoint proteins in meiosis
Gametes are produced via meiosis, a specialized cell division associated with frequent errors which cause birth defects and infertility. Uniquely in meiosis I, homologous chromosomes segregate to opposite poles, usually requiring their linkage by chiasmata, the products of crossover recombination1....
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-07-18 | PXD048251 | Pride
Chromosome segregation Mad3 Mad2 Saccharomyces cerevisiae Meiosis Spindle checkpoint 
ProteomicsMps1(Mph1) Kinase phosphorylates Mad3 to Inhibit Cdc20Slp1 –APC/C and maintain spindle checkpoint arrests
The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mads/BubR1 is a key component of the mitotic chec...
ORGANISM(S): Schizosaccharomyces pombe 
2016-03-31 | PXD003806 | Pride
Mad3 Kinase Mitosis Spindle Phosphorylation S.pombe 
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
ProteomicsConserved signalling functions for Mps1, Mad1 and Mad2 in the Cryptococcus neoformans spindle checkpoint
Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle checkpoint which regulates the metaphase ...
ORGANISM(S): Cryptococcus neoformans 
2024-05-27 | PXD052327 | Pride
Cryptococcus neoformans Mad2 Mad1 Spindle checkpoint Mps 
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