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MetabolomicsThe splicing paralogues SNRPB and SNRPN control differential metabolic states

Gene duplication is a major driver of biological complexity, yet the persistence of highly similar paralogous factors suggests the existence of context-dependent functions that remain incompletely understood. Certain conserved components of the mammalian RNA processing machinery exhibit striking ...

2026-02-09 | MTBLS13877 | MetaboLights
TranscriptomicsSRSF10 regulates alternative splicing and is required for adipocyte differentiation.
During adipocyte differentiation, significant alternative splicing changes occur in association with the adipogenic process. However, little is known about roles played by splicing factors in this process. We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired devel...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-54226 | biostudies-arrayexpress
TranscriptomicsThe epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate alternative splicing events
Epithelial Splicing Regulatory Proteins 1 and 2 (ESRP1 and ESRP2) are recently discovered epithelial-specific RNA-binding proteins that promote splicing of the epithelial variant of the FGFR2, ENAH, CD44, and CTNND1 transcripts. To catalogue a larger set of splicing events under the regulation of t...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-17468 | biostudies-arrayexpress
TranscriptomicsCombinatorial role of two paralogous splicing factors, hnRNP L and L-like, in multiple-exon regulation of CD45 alternative splicing
The goal of this study was to investigate the role of hnRNP L-like in alternative pre-mRNA splicing in human B-cells through an RNA-Seq approach. RNA-Seq was performed in DG75 cell line with over expression of hnRNP L-like or GFP as control.
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-33013 | biostudies-arrayexpress
TranscriptomicsRegulation of Vertebrate Nervous System-Specific Alternative Splicing and Development by an SR-Related Protein
Alternative splicing is a key process underlying the evolution of increased proteomic and functional complexity and is especially prevalent in the mammalian nervous system. However, the factors and mechanisms governing nervous system-specific alternative splicing are not well understood. Through a g...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-16187 | biostudies-arrayexpress
TranscriptomicsGlobal regulation of alternative splicing by adenosine deaminase acting on RNA (ADAR) [RNA-seq]
Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing machinery are only partially understood. Adenosine-to-inosine (A-to-I) RNA editing of pre-mRNA by ADAR enzymes has been...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47997 | biostudies-arrayexpress
TranscriptomicsProtein arginine methyltransferase AtPRMT5 is involved in pre-mRNA splicing in Arabidopsis thaliana
In this study, we analyzed the Arabidopsis homologue of PRMT5, AtPRMT5M-bM-^@M-^Ys function in RNA processing. RNA-seq analyses revealed that AtPRMT5 is involved in a subset of pre-mRNA splicing. Several RNA processing factors involved in regulating flowering time were validated that the correspondi...
ORGANISM(S): Arabidopsis thaliana 
2010-10-07 | E-GEOD-21323 | biostudies-arrayexpress
TranscriptomicsAn EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Regulation of cell-cell junction formation and regulation of cell migration were enriched among EMT (Epithelial-Mesenchymal Transition)-associated alternatively splicing events. Our analysis suggested that most EMT-associated alternative splicing events are regulated by one or more members of the RB...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30290 | biostudies-arrayexpress
TranscriptomicsRegulation of alternative splicing by the core spliceosomal machinery
Abstract: Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in gene regulation. However, the role of the basal splicing machinery in regulating AS remains poorly understood. Here we show that the core snRNP protein SmB/B’ self-regulates its expression by promo...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26463 | biostudies-arrayexpress
TranscriptomicsRBFOX1 Splicing and Transcriptional Regulation in Neurons
We used RNA sequencing to identify the RBFOX1 splicing network at a genome-wide level in primary human neural stem cells during differentiation. We observe that RBFOX1 regulates a large set of alternative splicing events implicated in neurogenesis and cell maintenance. Subsequent alterations in gene...
ORGANISM(S): Homo sapiens 
2012-06-28 | E-GEOD-36710 | biostudies-arrayexpress
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