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TranscriptomicsConnexin-dependent transcellular transcriptomic networks in mouse brain
Microarray experiments have generally focused on magnitude of gene expression changes in pathological conditions, thereby using the method as a high throughput screen to identify candidate marker genes and/or to validate phenotypic differences. We have used novel strategies to extract additional in...
ORGANISM(S): Mus musculus 
2010-06-09 | E-GEOD-6355 | biostudies-arrayexpress
TranscriptomicsSex-dependent gene regulatory networks of the heart rhythm
Expression level, control and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of 4 male and 4 female adult mice. We found that genes encoding various adrenergic receptors, ankyrins, ion channels and transporters, connexins and other compone...
ORGANISM(S): Mus musculus 
2009-08-12 | E-GEOD-17324 | biostudies-arrayexpress
TranscriptomicsTranscriptomic alterations induced by AT-EAE in mouse spinal cord
We compared RNA samples extracted from spinal cords of control (C) and AT-EAE (E) mice using the "Multiple Yellow" strategy. 4 distinct C-extracts were hybridized with two slides and 4 distinct E-extracts with other two slides, and the green/red normalized signals were compared separately and the E/...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2446 | biostudies-arrayexpress
TranscriptomicsEffect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes ass...
ORGANISM(S): Mus musculus 
2008-08-07 | E-GEOD-12312 | biostudies-arrayexpress
MetabolomicsProfiling aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile specific N-acyl amino acids

Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive metabolites and thus represent a potentially rich source of b...

2026-07-23 | MTBLS13404 | MetaboLights
TranscriptomicsTranscriptomic alterations in Trypanosoma cruzi-infected cardiac myocytes
Trypanosoma cruzi infection is a major cause of cardiomyopathy. Gene profiling studies of hearts from infected mice have revealed prominent changes in gene expression within many functional pathways. This variety of transcriptomic changes in infected mice raises the question of whether gene express...
ORGANISM(S): Mus musculus 
2010-05-15 | E-GEOD-17330 | biostudies-arrayexpress
UnknownStress gates an astrocytic energy reservoir to impair synaptic plasticity.
Not available
S-EPMC7181611 | biostudies-literature
ProteomicsClick-linking: a cell-compatible protein crosslinking method based on click chemistry
We developed a novel approach to in situ crosslinking mass spectrometry (XL-MS) where the reaction is split into two sequential and orthogonal coupling events. The method involves pre-stabilization of the proteome using a fixation protocol, followed by a two-step process that begins with extensive l...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-01-28 | PXD059118 | Pride
In situ Crosslinking Proteome-wide Protein-protein interactions Interactome 
ProteomicsIMProv: A Resource for Crosslink-Driven Structure Modeling that Accommodates Protein Dynamics
Crosslinking and hydrogren-deuterium exchange data of Polycomb Repressive Complex 2 used for integrative modelling.
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD022861 | Pride
Crosslinking mass spectrometry Software Integrative modelling 
ProteomicsCompounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
Enhancing the removal of aggregate-prone toxic proteins is a rational therapeutic strategy for a number of neurodegenerative diseases, especially Huntington’s disease and various spinocerebellar ataxias. Ideally, such approaches should preferentially clear the mutant/misfolded species, while having ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-15 | PXD034712 | Pride
Beclin 1 Atpase Smer28 Autophagy Ubiquitin-proteasome system Neurodegeneration Vcp Protein quality control 
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