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Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down Syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromoso...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-04-10 | PXD006009 | Pride
Imprinting describes the differential expression of alleles based upon their parent of origin. Deep sequencing of RNAs from maize endosperm and embryo tissue 14 days after pollination was used to identify imprinted genes among a set of ~12,000 genes that were expressed and contained sequence polymo...
ORGANISM(S): Zea mays 
We collected longitudinally human NK cells from patients after alloSCT (at days +90, +120, +180), to identify any potential functional NK cell defects on a protein level. We have focused our analysis on whole proteome patterns by analyzing patient NK cells stimulated with A. fumigatus or left unstim...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) Homo sapiens (Human) 
2026-04-30 | PXD068702 | Pride
Trimethylation of histone H3 lysine 27 (H3K27me3) plays a critical role in regulating gene expression during plant and animal development. We characterized the genome-wide distribution of H3K27me3 in five developmentally distinct tissues in maize plants of two genetic backgrounds, B73 and Mo17, rep...
ORGANISM(S): Zea mays 
DNA methylation is a chromatin modification that is frequently associated with epigenetic regulation in plants and mammals. However, other genetic changes such as transposon insertions also can lead to changes in DNA methylation levels. Genome-wide profiles of DNA methylation levels for 20 maize i...
ORGANISM(S): Zea mays 
Transposable elements have the potential to act as controlling elements to influence the expression of genes. The current paradigm suggests that heterochromatic silencing can spread beyond the borders of the transposable element and influence the chromatin state of neighboring low-copy sequences. ...
ORGANISM(S): Zea mays 
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