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ProteomicsRegulated biogenesis and targeting of monotopic squalene monooxygenase requires the GET pathway
This study investigated get3 mutant yeast cell. Proteins of the GET pathway are involved in targeting of C-terminally anchored transmembrane proteins and protection against lipotoxicity. Get3 cells revealed an altered ergosterol production and susceptibility towards a sterol synthesis inhibiting dru...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-06-09 | PXD027705 | Pride
In-gel digestion Erg1 Terbinafine Lipotoxicity Lfq Squalene monooxygenase Get3 Get pathway 
UnknownStrategies to Better Target Fungal Squalene Monooxygenase.
Not available
S-EPMC7828399 | biostudies-literature
UnknownA key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.
Not available
S-EPMC7132291 | biostudies-literature
UnknownHypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
Not available
S-EPMC9851614 | biostudies-literature
UnknownSqualene Monooxygenase Gene SsCI80130 Regulates Sporisorium scitamineum Mating/Filamentation and Pathogenicity.
Not available
S-EPMC9143649 | biostudies-literature
UnknownSqualene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis.
Not available
S-EPMC11442994 | biostudies-literature
UnknownThe mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.
Not available
S-EPMC8166775 | biostudies-literature
ProteomicsViperin inhibits cholesterol biosynthesis and interacts with enzymes in the cholesterol biosynthetic pathway
Many enveloped viruses bud from cholesterol-rich lipid rafts on the cell membrane. Depleting cellular cholesterol impedes this process and results in viral particles with reduced viability. Viperin (virus inhibitory protein endoplasmic reticulum-associated, interferon-induced) is an ER membrane-as...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023999 | Pride
Viperin  cholesterol regulation  interactome analysis  radical sam enzyme  squalene monooxygenase  lanosterol synthase 
UnknownSterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
Not available
S-EPMC3721249 | biostudies-literature
UnknownIncreased copy number of the target gene squalene monooxygenase as the main resistance mechanism to terbinafine in Leishmania infantum.
Not available
S-EPMC10502319 | biostudies-literature
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