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ProteomicsSystematic investigation of protein phosphorylation in biomolecular condensates
We have adapted a recently developed quantitative proteomics based approach to measure protein solubility following a lysate centrifugation assay to determine the proportion of a protein in distinct subpopulations in a proteome-wide manner (Sridharan et al., 2019). Further, by combining the solubili...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD027769 | Pride
Protein solubility Phosphorylation Biomolecular condensate 
TranscriptomicsGene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12380 | biostudies-arrayexpress
Unknowntert-Butyl 3-amino-5-bromo-1H-indazole-1-carboxyl-ate.
Not available
S-EPMC9462357 | biostudies-literature
TranscriptomicsRNA-seq analysis of bronchosphere cultures of primary human bronchiolar epithelial cells
Primary human bronchial epithelial cells were transduced with control or hYAP(S127A) lentivirus in sphere forming conditions. Bronchospheres were harvested on day 18-20 for RNAseq analysis Passage 1 Primary HBECs from 2 independent donors were transduced with control or hYAP lentivirus. 48 hours pos...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-61626 | biostudies-arrayexpress
UnknownComparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats.
Not available
S-EPMC5209405 | biostudies-literature
ProteomicsProteome wide solubility profiling of Nucleozin treated A549 cells infected with Influenza-A
A549 WT and Rab11 deleted cell lines were infected with influenza-A and treated with nucleozin. We have evaluated the effect of an antiviral drug, nucleozin, on protein solubility at 13 hpi with influenza-A virus.
ORGANISM(S): Homo sapiens (Human) 
2023-04-23 | PXD041748 | Pride
Antiviral Phase transition Infection. lc-ms-ms 
UnknownCancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer coculture.
Not available
S-EPMC6294935 | biostudies-literature
TranscriptomicsComparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants
Mycobacterium tuberculosis, a pathogen of global importance, utilizes the ESX-1 protein secretion system to export virulence factors that disarm host macrophages. Although this secretory pathway is critical for virulence, how ESX-1 is regulated is completely unknown. Here we show that EspR (Rv3849) ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-12381 | biostudies-arrayexpress
TranscriptomicsDrosophila PTB regulates dorso-ventral patterning genes in embryos
Drosophila PTB (Polypyrimidine Tract-binding protein dmPTB) regulates dorso-ventral patterning genes in embryos Comparison of wild type (yw genotype) and PTB mutant (heph03429) drosophila embryos
ORGANISM(S): Drosophila melanogaster 
2014-05-10 | E-GEOD-57517 | biostudies-arrayexpress
ProteomicsKDM3A and KDM3B Maintain Naïve Pluripotency Through the Regulation of Alternative Splicing
Histone modifying enzymes play a central role in maintaining cell identity by establishing a conducive chromatin environment for lineage specific transcription factor activity. Pluripotent embryonic stem cells (ESCs) identity is characterized by lower abundance of gene repression associated histone ...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-23 | PXD042735 | Pride
Flag-ip Mescs Histone demethylases 
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