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ProteomicsIdentification of novel Kv1.3 channel-interacting proteins using proximity labelling in T-cells
Potassium channels regulate membrane potential, calcium flux, cellular activation and effector functions of adaptive and innate immune cells. The voltage-activated Kv1.3 channel is an important regulator of T cell-mediated autoimmunity and microglia-mediated neuroinflammation. Kv1.3 channels, via pr...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD059644 | Pride
Autoimmune disease T-cells Potassium channel Kv1.3 
ProteomicsNeuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons
In this study, we have applied cell type-specific in vivo biotinylation of proteins (CIBOP) to label Camk2a excitatory neuronal proteomes, and imposed differential centrifugation to prepare synaptosome-enriched fractions, followed by proteomic analysis of biotinylated neuronal proteins. This approac...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-13 | PXD068874 | Pride
Mitochondria Excitatory neuron Neuroinflammation Synapse vulnerability Alzheimer's disease Cognitive resilience Mapk signaling Native-state proteomics Synaptosome 
ProteomicsPathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of prodromal Alzheimer’s disease
Alzheimer’s disease (AD), though defined as a cognitive disorder, often presents neuropsychiatric symptoms such as anxiety, depression, agitation and sleep disruptions years before the onset of frank memory impairment. A hallmark prodromal feature is the accumulation of hyperphosphorylated “pretangl...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-22 | PXD071656 | Pride
Alzheimer’s disease Locus coeruleus (lc) 
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