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ProteomicsProtein folding stabilities are a major determinant of oxidation rates for buried methionine residues
The oxidation of protein-bound methionines to form methionine sulfoxides has a broad range of biological ramifications and it is therefore important to delineate factors that influence methionine oxidation rates within a protein. Previously, neighboring residue effects and solvent accessibility (SA)...
ORGANISM(S): Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) Escherichia coli 
2022-04-22 | PXD030245 | Pride
Protein stability Methionine Lumos Quantitative proteomics Oxidation-reduction 
ProteomicsMManassantin A iTRAQ-SPROX Drug Mode-of-Action
Manassantin A is a natural product that has been isolated from the perennial herb Saururus chinensis Baill and the aquatic plant Saururus cernuus. Manassantin A has been shown to possess potent hypoxia inducible factor 1 alpha (HIF-1α) inhibitory activity in a cell-based assay screen of thousands o...
ORGANISM(S): Homo sapiens (Human) 
2016-07-12 | PXD002304 | Pride
Drug mode-of-action Stability of proteins from rates of oxidation (sprox) Mda-mb-231 Protein-ligand binding interactions Manassantin a Itraq 
ProteomicsDiscovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome
Described here is the application of thermodynamic stability measurements to study age-related differences in the protein folding and stability of proteins in a rodent model of ageing. Using the Stability of Proteins from Rates of Oxidation (SPROX) technique the thermodynamic stability profiles wer...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-22 | PXD005184 | Pride
Mouse Ageing Sprox Itraq 
ProteomicsTop-Down Stability of Proteins from Rates of Oxidation (SPROX) Approach for Measuring Proteoform Specific Folding Stability
Raw data files and TDreport for the manuscript "Top-Down Stability of Proteins from Rates of Oxidation (SPROX) Approach for Measuring Proteoform Specific Folding Stability"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-07 | MSV000095546 | MassIVE
UnknownTop-Down Stability of Proteins from Rates of Oxidation (TD-SPROX) Approach for Measuring Proteoform-Specific Folding Stability.
Not available
S-EPMC11809260 | biostudies-literature
ProteomicsDiscovery of the Xenon-Protein Interactome using Large-Scale Measurements of Protein Folding and Stability
The intermolecular interactions of noble gases in biological systems are associated with numerous biochemical responses, including apoptosis, inflammation, anesthesia, analgesia, and neuroprotection. The molecular modes of action underlying these responses are largely unknown. This is in large part ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD029353 | Pride
Noble gases Protein stability Sprox Limited proteolysis 
ProteomicsDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006732 | Pride
Silac Tamoxifen Sprox Mcf-7 N-desmethyl tamoxifen 
ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using SILAC-SPROX
Proteomic methods for disease state characterization and biomarker discovery have traditionally utilized quantitative mass spectrometry methods to identify proteins with altered expression levels in disease states. Here we report on the large-scale use of protein folding stability measurements to ch...
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD006703 | Pride
Mcf-7 Chemical denaturation Bt-474 Mda-mb-468 Protein folding 
ProteomicsGlobal Stability Profling of Colorectal Cancer Chemoresistance
Almost half of the patients with advanced colorectal cancer (CRC) are resistant to oxaliplatin based therapy, the first line treatment for CRC. Therefore, predicting and understanding oxaliplatin resistance is important to improve CRC patient survival. Investigated here is the use of proteomic foldi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-04-28 | PXD036298 | Pride
Colorectal cancer Oxaliplatin Sprox Tpp Lip 
ProteomicsDiscovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements, part 2
The proteins in an MCF-7 cell line were probed for tamoxifen (TAM) and n-desmethyl tamoxifen (NDT) induced stability changes using the Stability of Proteins from Rates of Oxidation (SPROX) technique in combination with two different quantitative proteomics strategies. Together the SILAC- and iTRAQ-S...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD006747 | Pride
Tamoxifen Sprox N-desmethyl tamoxifen 
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