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ProteomicsC-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2
Mapping proteomic composition at distinct genomic loci and subnuclear landmarks in living cells has been a long-standing challenge. Here we report that dCas9-APEX2 Biotinylation at genomic Elements by Restricted Spatial Tagging (C-BERST) allows the unbiased mapping of proteomes near defined genomic ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-07 | PXD009216 | Pride
Apex2 Biotinylation Centromere Proteomes Cas9 Subnuclear Telomere 
TranscriptomicsTGF-β Tumor Suppression Through A Lethal EMT
TGF-β is a major tumor suppressor in gastrointestinal (GI) and squamous carcinomas, which exhibit frequent genetic inactivation of Smad4, a key TGF-β signaling component. Apoptosis is implicated as an important mediator of the tumor suppressive function of TGF-β, although this process remains poo...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-72069 | biostudies-arrayexpress
UnknownPervasive hybridizations in the history of wheat relatives.
Not available
S-EPMC6494498 | biostudies-literature
UnknownPrimiparous sow behaviour on the day of farrowing as one of the primary contributors to the growth of piglets in early lactation.
Not available
S-EPMC11310322 | biostudies-literature
UnknownHealth risks of airplane boarding methods with apron buses when some passengers disregard safe social distancing.
Not available
S-EPMC9342771 | biostudies-literature
ProteomicsRole of Nse1 subunit of SMC5/6 complex as a ubiquitin ligase
Structural Maintenance of Chromosomes (SMC) complexes - cohesin, condensin and SMC5/6 - are important for many aspects of the chromosomal organization. These complexes are composed of Smc and non-Smc element (Nse) subunits. The Nse1 subunit of SMC5/6 contains a variant RING domain, characteristic of...
ORGANISM(S): Homo sapiens (Human) Schizosaccharomyces pombe 927 
2022-01-24 | PXD029573 | Pride
Liquid chromatography Mass spectrometry Ubiquitination Smc5/6  nse1 Ubiquitin ligase 
TranscriptomicsTranscriptional profiling of M. tuberculosis CDC1551 wild type vs aprABC null, aprBC null, aprC null and phoP transposon mutants.
Following phagocytosis by macrophages, Mycobacterium tuberculosis (Mtb) senses the intracellular environment and remodels its gene expression for growth in the phagosome. Abramovitch et.al. in this current study identified an Acid and Phagosome Regulated (aprABC) locus that is unique to the Mtb comp...
ORGANISM(S): Mycobacterium tuberculosis 
2011-07-09 | E-GEOD-22854 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in endothelial precursor cells of patients protected from microvascular complications
In this study, we examined the impact of modulating the TGF-β/PAI-1 axis in CD34+ cells function from diabetic patients and controls. Using gene array studies, we found that diabetics, protected from microvascular complications despite suboptimal glycemic control, had reduced level of TGF- β1 and P...
ORGANISM(S): Homo sapiens 
2013-02-01 | E-GEOD-43950 | biostudies-arrayexpress
UnknownVitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis.
Not available
S-EPMC6049814 | biostudies-literature
UnknownPredicting modular functions and neural coding of behavior from a synaptic wiring diagram.
Not available
S-EPMC11614741 | biostudies-literature
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