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ProteomicsA novel method for creating a synthetic L-DOPA proteome and in vitro evidence of incorporation.
Proteinopathies are protein misfolding diseases that have an underlying factor that effect the conformation of proteoforms. A factor hypothesised to play a role in these diseases is the incorporation of non-protein amino acids into proteins, with a key example being the therapeutic drug levodopa. Th...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025759 | Pride
Misincorporation  post translational modifications  ptm  levodopa  l-dopa 
ProteomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Reduction in blood supply to the kidneys occurs to certain extent during kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. At present, no therapies exist to prevent the AKI to CKD transition. Here, we presen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD042882 | Pride
Acute kidney injury Metabolomics Organoids Chronic kidney disease Transcriptomics Maladaptive regeneration Proteomics Hypoxia 
ProteomicsHaptoglobin and glutamine synthetase as potential biomarkers of chemotherapy-induced cachexia in skeletal muscle
Cancer cachexia is a multifactorial wasting syndrome affecting body and lean tissue mass that is often exacerbated by anticancer chemotherapy. In this study, we used a mouse model of acute myeloid leukemia chemotherapy induction regimen (CIR) comprising daunorubicin and cytarabine to investigate the...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-16 | PXD063910 | Pride
Cancer cachexia Proteomics Skeletal muscle wasting Glutamine synthetase Tmt Mitochondrial metabolism Acute myeloid leukemia Haptoglobin Chemotherapy Biomarkers Aml 
ProteomicsAtrogin-1 regulates BiP levels - novel therapeutic targets for Duchenne Muscular Dystrophy
Skeletal muscle wasting results from numerous pathological conditions impacting both the musculoskeletal and nervous systems. A unifying feature of these pathologies is the upregulation of members of the E3 ubiquitin ligase family, resulting in increased proteolytic degradation of target proteins. ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2024-03-07 | PXD038406 | Pride
Atrogin-1  bip  duchenne muscular dystrophy zebrafish 
ProteomicsMenstrual fluid-derived extracellular vesicles as a non-invasive diagnostic tool for endometriosis
Introduction: Endometriosis is a debilitating condition where endometrial-like tissue grows outside the uterus and rarely in distant sites such as the lungs, heart and brain. Symptoms are severe chronic pain, bladder/bowel problems, painful sex and infertility. Differences in endometrium between wom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042101 | Pride
Endometriosis Extracellular vesicles Non-invasive diagnosis Menstrual fluid 
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