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ProteomicsMagnolia officinalis (L.) Bark Extract Counteracts Oxidative Brain In-jury: A Proteomic Investigation into Neuroprotective Mechanisms
Neurodegenerative diseases involve progressive neuronal loss associated with oxidative stress (OS) and inflammation. Given the limited efficacy of current therapies, natural compounds with multitarget neuroprotective potential are of growing interest. In this study, we investigated the neuroprotecti...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-05-25 | PXD075711 | Pride
Rat Label-free proteomics Magnolia officinalis (l.) Phytochemicals Age-related disor-ders Oxidative stress Neuroprotection Lc-hrms/ms 
TranscriptomicsTranscription profiling of pig alveolar macrophages infected with Porcine Respiratory Reproductive Syndrome Virus
A primary culture of Porcine Alveolar Macrophages (PAM) from six animals was split in two: one was infected at a multiplicity of infection (MOI) of 10 with a 13th passage of PRRSV Lelystad virus. The other culture was maintained as control. The percentage of infected cells ranged between 60 and 70% ...
ORGANISM(S): Sus scrofa 
2008-07-01 | E-MEXP-1350 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of porcine alveolar macrophages (PAM) after antibody-mediated crosslinking of sialoadhesin (Sn, Siglec-1)
In the present study, Sn expressed on primary pig macrophages was crosslinked with the anti-Sn monoclonal antibody 41D3 and the mRNA expression profiles were compared, using the Affymetrix microarray technology, to macrophages incubated with the irrelevant, isotype matched, monoclonal antibody 13D12
ORGANISM(S): Sus scrofa 
2007-03-09 | E-MEXP-991 | biostudies-arrayexpress
ProteomicsAcacia Catechu Willd extract protects neuronal cells from oxidative stress-induced damage
Oxidative stress (OS) resulting in reactive oxygen species (ROS) generation and inflammation, play a pivotal role in the neuronal loss occurring in neurodegenerative diseases. Therefore, promising future drugs that would prevent or slow down the progression of neurodegeneration should possess potent...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-16 | PXD029239 | Pride
Brain Rat Acacia catechu Lc-hrms/ms 
ProteomicsPerturbations of the proteome in primary astrocytes from the hSOD1(G93A) ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose pathophysiology is largely unknown. Despite motor neuron death is recognized as the key event in ALS, astrocytes dysfunctionalities and neuroinflammation were demonstrated to accompany and probably even drive motor ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026576 | Pride
Spinal cord astrocytes Amyotrophic lateral sclerosis Mouse Lc-hrms/ms 
ProteomicsSerum metabolomics and proteomics to study the antihyperten-2 sive effect of Tenebrio molitor extracts
This study aimed at integrating metabolomics and proteomics data for a comprehensive view of the molecular targets of intervention of protein extracts from Tenebrio molitor in treating hypertension. Serum samples from spontaneously hypertensive rats and Wistar Kyoto rats were analyzed using a quanti...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-10-13 | PXD034456 | Pride
Functional food  multi-omics  blood pressure  shr rats  insect protein supplementation 
UnknownAvidity observed between a bivalent inhibitor and an enzyme monomer with a single active site.
Not available
S-EPMC8631645 | biostudies-literature
TranscriptomicsTranscriptional analysis of oxidative-stressed bean nodules elicited by Rhizobium etli expressing an heterologous globin (VHb)
A wide range of environmental stresses lead to an elevated production of reactive oxygen species (ROS) in plant cells thus resulting in oxidative stress. The biological nitrogen fixation in the legume - Rhizobium symbiosis is at high risk of damage from oxidative stress. Common bean (Phaseolus vulga...
ORGANISM(S): Phaseolus vulgaris 
2016-06-15 | E-GEOD-83324 | biostudies-arrayexpress
TranscriptomicsTranscript Profiling of the Common Bean - Rhizobium Symbiosis under Oxidative Stress
A wide range of environmental stresses lead to an elevated production of reactive oxygen species (ROS) in plant cells thus resulting in oxidative stress. The biological nitrogen fixation in the legume - Rhizobium symbiosis is at high risk of damage from oxidative stress. Common bean (Phaseolus vulga...
ORGANISM(S): Phaseolus vulgaris 
2012-06-30 | E-GEOD-37638 | biostudies-arrayexpress
TranscriptomicsCommon bean (Phaseolus vulgaris) PvTIFY orchestrates global changes in transcript profile response to phosphorus deficiency
TIFY is a large plant-specific transcription factor gene family. A subgroup of TIFY genes named JAZ (Jasmonate-ZIM domain) has been identified as repressors of jasmonate (JA)-regulated transcription in Arabidopsis and other plants. JA signaling is involved in many aspects of plant growth/development...
ORGANISM(S): Phaseolus vulgaris 
2013-02-27 | E-GEOD-40935 | biostudies-arrayexpress
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