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ProteomicsDe novo BCR-ABL linear kinase motifs revealed by phosphoproteomics in yeast
Protein tyrosine phosphorylation (pY) is central to many cellular signaling pathways. Deregulation of pY can lead to malignancies such as leukemia. Thus, assigning kinase-substrate relations is imperative to understand disease alterations. However, such efforts are complicated by kinase redundancy, ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD038551 | Pride
Bcr-abl Ksea Phosphoproteomics Abl Linear sequence motif Protein tyrosine phosphorylation 
ProteomicsThe RNA helicase Dbp10 coordinates assembly factor association with PTC formation during ribosome biogenesis
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase Dbp10 is suggested to restructure pre-ribosomal rRNA of the evolving peptidyl-transferase center (PTC) on nucleolar ribosom...
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-05-22 | PXD046068 | Pride
Ribosome assembly. pre-60s Assembly factors S. cerevisiae 
ProteomicsRecurrent innovation of protein-protein interactions in the Drosophila piRNA pathway
Despite being essential for fertility, genome defence pathway genes often evolve rapidly. However, little is known about the molecular basis of this adaptation. Here, we characterize the evolution of a protein interaction network within the PIWI-interacting small RNA (piRNA) genome defence pathway i...
ORGANISM(S): Drosophila persimilis Drosophila simulans Drosophila virilis Drosophila melanogaster (Fruit fly) Drosophila erecta 
2024-10-05 | PXD053049 | Pride
Pirna pathway Inter and intra lethalities Drosophila Species-specific protein interactions Evolution 
ProteomicsMutational scanning pinpoints distinct binding sites of key ATGL regulators in lipolysis
ATGL is the key enzyme in intracellular lipolysis playing a critical role in metabolic and cardiovascular diseases. ATGL is tightly regulated through a known set of protein-protein interaction partners with activating or inhibiting functions in control of lipolysis. However, the binding mode and pro...
ORGANISM(S): Homo sapiens (Human) 
2024-03-14 | PXD049436 | Pride
Deep mutagenesis Cidec Plin5 Plin1 Atgl G0s2 Cgi-58 
UnknownMultiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.
Not available
S-EPMC4712676 | biostudies-literature
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