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ProteomicsThe anti-MRSA compound KCR inhibits protein synthesis in Staphylococcus aureus
S aureus was treated in triplicate with 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside (KCR), oxacillin or vehicle and quantitative proteomic analysis was carried out using isobaric tags and mass spectrometry. 1190 proteins were identified and 552 were affected by KCR (q<0.01). Ontology analysis ide...
ORGANISM(S): Staphylococcus Aureus (ncbitaxon:1280) 
MSV000084282 | MassIVE
GenomicsGenomic Characterization of Meningiomas

Meningiomas are the most common primary brain tumor in the US. Although the tumor suppressor gene NF2 is disrupted in approximately half of meningiomas, the complete spectrum of genetic changes in meningiomas remains poorly understood, particularly in the large subset of tumors without NF2 altera...

phs000552.v1.p1 | EGA
Unknown4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.
Not available
S-EPMC7935017 | biostudies-literature
ProteomicsProteomic analysis of CRISPR Cas 9 mediated mdig deletion in triple negative breast cancer cells
Background Breast cancer is the leading cause of cancer related deaths in women. Triple negative breast cancers are highly aggressive, have an overall poor prognosis and has limited therapeutic options. Previously, we have identified an environmental induced gene mdig that predicted the overall surv...
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD016688 | Pride
Breast cancer Mass spectrometry Mdig Signaling pathways Biomarker 
ProteomicsProteomics analysis of rough endoplasmic reticulum in pancreatic beta cells
Pancreatic beta cells have well-developed endoplasmic reticulum (ER) to accommodate for the massive production and secretion of insulin. ER homeostasis is vital for normal beta cell function. Perturbation of ER homeostasis contributes to beta cell dysfunction in both type 1 and type 2 diabetes. To s...
ORGANISM(S): Mus musculus (Mouse) 
2015-04-15 | PXD001081 | Pride
Insulin biogenesis Pancreatic beta cells Endoplasmic reticulum Gelc-ms/ms 
UnknownProteomics analysis of rough endoplasmic reticulum in pancreatic beta cells.
Not available
S-EPMC4489703 | biostudies-literature
UnknownDeletion of mdig enhances H3K36me3 and metastatic potential of the triple negative breast cancer cells.
Not available
S-EPMC9482110 | biostudies-literature
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
UnknownGenomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.
Not available
S-EPMC4916970 | biostudies-literature
ProteomicsHUPO Plasma Proteome Project - Advancement of biomarker discovery and validation through the HUPO plasma proteome project
esi-quadrupole tof survey of tryptic peptides from HUPO pooled Human plasma or serum specimen: b1-serum.
ORGANISM(S): Homo sapiens (Human) 
2007-04-23 | PRD000002 | Pride
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