Stemness maintenance

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D-Fructose 1,6-bisphosphate (2)
ACar 24:2 (1)
4-(3-methyl-1-phenyl-1H-pyrazolo[3,4-b]quinolin-4-yl)morpholine (1)
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PC (20:1/20:2) (1)
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5alpha-Pregnan-3,20-dione (1)
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IsPrivate

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Modelling Approach

Logical model (1)

Study type

Transcription profiling by array (38)
ChIP-seq (8)
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Methylation profiling by high throughput sequencing (3)
ChIP-chip by tiling array (1)
Cell line - High-throughput sequencing (1)
ChIP-chip by array (1)
Other (1)
RNA-seq of coding RNA from single cells (1)

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Lab affiliation

Chemistry of Life Processes Institute, Proteomic Center of Excelence, Northwestern University, USA (1)
Children’s Hospital of Philadelphia 3615 Civic Center Blvd. Philadelphia, PA 19104 (1)
Departamento de Biología Celular, Biología Funcional y Antropología Física,Instituto de Biotecnología y Biomedicina (1)
Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Republic of Korea (1)
Institut I für Anatomie AG Molekulare Zellbiologie Universität zu Köln Kerpener Str. 62, Geb. 37 D-50937 Cologne Germany (1)
Institute of Molecular Medicine and Genetics, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, China. (1)
Laboratory of Animal Histology, Faculty of Biology, “Alexandru Ioan Cuza” University of Iasi, Carol I Bvd. No. 22, Iasi 700505, Romania (1)
Leibniz Institute on Aging - Fritz Lipmann Institute FLI (1)
Model Animal Research Center, Medical School, Nanjing University (1)
Professor & Head, Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India (1)
Shaanxi normal university (1)
Singapore Eye Research Institute (1)
Singapore Eye Research Institute, Ocular Proteomics Lab (1)
Tianjin Medical University Cancer Institute and Hospital (1)
University of North Carolina, Chapel Hill (1)

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Extracellular-acidosis restricts one-carbon metabolism and preserves T cell stemness

The accumulation of acidic metabolic waste products within the tumor microenvironment profoundly inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it is unclear whether extracellular-acidosis impacts T cell metabolic fitness and differentiation status. Here, we surprisin...

2023-01-17 | MTBLS6661 | MetaboLights

CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells

Cancer stem cells (CSCs) play crucial roles in cancer progression, immune evasion, drug resistance, and recurrence. Understanding the mechanisms behind CSCs generation and stemness maintenance is vital for early cancer diagnosis and treatment. Here, we unveil that carnitine palmitoyltransferase 1A (...

ORGANISM(S): Homo sapiens (Human)

2025-05-07 | PXD059026 | Pride

Epigenetic Maintenance of Stemness and Malignancy in Peripheral Neuroectodermal Tumors by EZH2

Chromatin modifications are increasingly recognized as a key mechanism in cancer. The histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) is the enzymatic subunit of the polycomb PRC2 complex and methylates histone H3K27, thereby, mediating gene silencing. Down-regulation of E...

ORGANISM(S): Homo sapiens

2010-05-18 | E-GEOD-15890 | biostudies-arrayexpress

SOX4 supports cancer stemness by enhancing HDAC1 transcription revealed by comparative proteomics

We have investigated the proteome changes induced by SOX4 overexpression in HCT-116 cells using iTRAQ-based quantitative proteomics. Bioinformatics analysis revealed that HDAC1 could be one of the important regulators in cancer stem cells (CSCs) maintenance. We found that SOX4 transcriptionally regu...

ORGANISM(S): Homo sapiens (Human)

2021-09-09 | PXD019694 | Pride

Sox4 Hdac1 Cancer stemness Comparative proteomics

Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

PRJNA990662 | ENA

Tumor cell-intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

PRJNA990673 | ENA

CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells by enhancing mitochondria-associated membranes formation

PRJNA1141517 | ENA

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling.

Not available

S-EPMC5708569 | biostudies-literature