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ProteomicsTarget Identification of Lagunamide A
Lagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsi...
ORGANISM(S): Homo sapiens (Human) 
2024-06-09 | PXD042129 | Pride
Natural product Tmt-10plex Lagunamide a Thermal proteome profiling Target id 
TranscriptomicsAlzheimer's disease and the normal aged brain (steph-affy-human-433773)
Information about the genes that are preferentially expressed during the course of Alzheimer’s disease (AD) could improve our understanding of the molecular mechanisms involved in the pathogenesis of this common cause of cognitive impairment in older persons, provide new opportunities in the diagnos...
ORGANISM(S): Homo sapiens 
2006-07-10 | E-GEOD-5281 | biostudies-arrayexpress
ProteomicsPronucleotide probes reveal a diverging specificity for AMPylation vs. UMPylation of human and bacterial nucleotide transferases
AMPylation is a post-translational modification utilized by human and bacterial cells to modulate the activity and function of specific proteins. Major AMPylators such as human FICD and bacterial VopS have been studied extensively for their substrate and target scope in vitro. Recently, an AMP pronu...
ORGANISM(S): Homo sapiens (Human) 
2024-02-27 | PXD045925 | Pride
Infection Ampylation Vops Umpylation Pronucleotide 
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons and Drd2+ Medium Spiny Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13384 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, cocaine treatment
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13386 | biostudies-arrayexpress
TranscriptomicsComparative analysis of Drd1+ Medium Spiny Neurons, Drd2+ Medium Spiny Neurons, Motor Neurons, and Purkinje Neurons
The cellular heterogeneity of the brain confounds efforts to elucidate the biological properties of distinct neuronal populations. Using Bacterial Artificial Chromosome (BAC) transgenic mice which express EGFP-tagged ribosomal protein L10a in defined cell populations, we have developed a methodology...
ORGANISM(S): Mus musculus 
2008-11-14 | E-GEOD-13387 | biostudies-arrayexpress
ProteomicsTarget identification of usnic acid in bacterial and human cells
Usnic acid is a natural product with versatile biological activities against various organisms. We here utilize a chemical proteomic strategy to gain insights into its target scope in bacterial and human cells. First, we excluded DNA binding as a major reason for its antibacterial activity and secon...
ORGANISM(S): Homo sapiens (Human) Enterococcus faecalis (Streptococcus faecalis) 
2024-08-10 | PXD049013 | Pride
Abpp Usnic acid 
ProteomicsThermal Proteome Profiling Chlorotonil derivative in S. aureus USA300
The protein targets of Chlorotonil derivative ChB1-Epo2 were analysed by thermal proteome profiling in S. aureus USA300 cells.
ORGANISM(S): Staphylococcus aureus 
2025-03-08 | PXD051670 | Pride
Thermal proteome profiling Tmt Chlorotonil 
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownViral resuppression and detection of drug resistance following interruption of a suppressive non-nucleoside reverse transcriptase inhibitor-based regimen.
Not available
S-EPMC2745911 | biostudies-literature
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