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ProteomicsRapid degradation pathways of host proteins during HCMV infection revealed by quantitative proteomics
Human cytomegalovirus is an important pathogen in immunocompromised individuals and neonates, and a paradigm for viral immune evasion. We previously developed a quantitative proteomic approach that identified 133 proteins degraded during the early phase of HCMV infection, including known and novel a...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2021-01-08 | PXD021961 | Pride
Human Hcmv Bortezomib Tmt Lc-ms3 Proteasome Mg132 
ProteomicsHigh definition analysis of protein stability during cytomegalovirus infection informs on cellular restriction
Human cytomegalovirus (HCMV) is an important pathogen and a paradigm of viral immune evasion. Here, we describe a multiplexed approach to discover proteins with novel innate immune functions on the basis of their active proteasomal or lysosomal degradation during the early phase of HCMV infection. U...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2018-08-16 | PXD009945 | Pride
Innate immunity Immune evasion Lysosome Restriction factor Host-pathogen interaction Proteasome Protein degradation Tandem mass tag Quantitative proteomics Pulsed silac 
UnknownDeciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Not available
S-EPMC10094749 | biostudies-literature
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