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MetabolomicsZika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA

ZIKV infection is associated with testicular damage and abnormal spermatogenesis. However, the molecular mechanisms underlying these pathogenic processes remain unclear. Here, we demonstrate that ZIKV disrupts Leydig cells' ability to produce testosterone, leading to decreased sperm counts and mo...

2025-06-29 | MTBLS12549 | MetaboLights
ProteomicsComprehensive and quantitative analysis of the changes in proteomic and phosphoproteomic profiles during stimulation and repression of steroidogenesis in MA-10 Leydig cells.
In the present study, we have used a quantitative LC-MS/MS approach using total and phosphopeptide-enriched proteins to identify the changes that occur in the proteome and phosphoproteome of MA-10 Leydig cells during both the stimulatory phase (Fsk/cAMP treatment) and inhibitory phase (AICAR-mediate...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-10-17 | MSV000090539 | MassIVE
TranscriptomicsEffect of AMPK activation by AICAR on MA-10 Leydig cell transcriptome
Steroid hormones regulate essential physiological processes and inadequate levels are associated with various pathological conditions. In testosterone-producing Leydig cells, steroidogenesis is strongly stimulated by LH via its receptor leading to increased cAMP production and expression of the ster...
ORGANISM(S): Mus musculus 
2014-08-19 | E-GEOD-50118 | biostudies-arrayexpress
TranscriptomicsscRNAseq of Cyp11a1-expressing cells from mouse melanoma model derived tumors
Tumours induce de novo steroidogenesis in immune cells. We wanted to define the gene expression identity of intratumoural steroidogenic immune cells and compare them with the transcriptome with non-steroidogenic cells. Cyp11a1 expression is a faithful biomarker of de novo steroidogenesis (i.e. Cyp11...
ORGANISM(S): Mus musculus 
2020-05-27 | E-MTAB-8509 | biostudies-arrayexpress
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079140 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
ProteomicsCell-intrinsic steroidogenesis regulates mast cell function
Steroid hormones are well known regulators of mast cell function, but whether mast cells themselves produce steroids de novo and influences their effector function has remained unknown. Here, we show that mast cells constitutively express the steroidogenic enzyme Cyp11a1 and produce pregnenolone. Cy...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-04 | PXD079414 | Pride
Mast cell degranulation Cyp11a1 Mast cell Steroid-signalling   anaphylaxis Steroidogenesis Pregnenolone 
GenomicsPerturbing local steroidogenesis to improve breast cancer immunity
Perturbing local steroidogenesis to improve breast cancer immunity
PRJNA1075107 | ENA
GenomicsComprehensive analysis of adrenocortical steroidogenesis in human and mouse
Comprehensive analysis of adrenocortical steroidogenesis in human and mouse
PRJNA391696 | ENA
GenomicsPrimitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function
Primitive steroidogenesis in mast cells: A novel regulatory mechanism for mast cell function
PRJNA1463298 | ENA
ModelsKumbale 2025 - T&A Model to Assess the Impact of Dioxin on Cholesterol and Steroidogenesis
Multiscale model to assess the impact of dioxin exposure on cholesterol dynamics and steroidogenesis. This model is represented as a Template and Anchor Model (T&A). We use Generalized Mass Action ( GMA; i.e., power law) within this multiscale modeling framework.
2025-02-11 | MODEL2502110001 | BioModels
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