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ProteomicsAllosteric transcription stimulation by super elongation complex
The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and a subcomplex, ELL2-EAF1, which stimulates transcription elongation by RNA polymerase II (Pol II). Here we report the cryo-EM structure of ELL2-EAF1 bound to a Pol II elongation complex at 2.8 Å re...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-07-15 | PXD024457 | Pride
Super elongation complex Stimulation of transcription elongation Transcription Eaf1 P-tefb Pol ii protrusion Rna polymerase ii Ell2 Tfiif 
GenomicsGlobal impact of RNA polymerase II elongation inhibition on alternative splicing regulation (ChIP-Seq)
The rate of RNA polymerase II (pol II) elongation can influence splice site selection in nascent transcripts, yet the extent and physiological relevance of this kinetic coupling between transcription and alternative splicing is not well understood. We performed experiments to perturb pol II elongati...
ORGANISM(S): Homo sapiens 
2010-12-09 | E-GEOD-25494 | biostudies-arrayexpress
TranscriptomicsThe SEC family of RNA Polymerase II elongation factors: gene target specificity and transcriptional output
The elongation stage of transcription is a highly regulated in metazoan. We previously purified the AFF1/AFF4-containing Super Elongation Complex (SEC) as a major regulator of development and cancer pathogenesis. Here, we report the biochemical isolation of SEC-like 2 (SEC-L2) and SEC-like 3 (SEC-L3...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-34097 | biostudies-arrayexpress
GenomicsKAP1 negatively regulates elongation kinetics to activate signal-induced transcription [RNA-Seq]
KAP1 negatively regulates elongation kinetics to activate signal-induced transcription [RNA-Seq]
PRJNA1108275 | ENA
GenomicsKAP1 negatively regulates elongation kinetics to activate signal-induced transcription [TT-Seq]
KAP1 negatively regulates elongation kinetics to activate signal-induced transcription [TT-Seq]
PRJNA1108274 | ENA
GenomicsFunctional association of Gdown1 with RNA Polymerase II in Human
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-01-13 | E-GEOD-32442 | biostudies-arrayexpress
GenomicsKAP1 negatively regulates elongation kinetics to activate signal-induced transcription [PRO-Seq]
KAP1 negatively regulates elongation kinetics to activate signal-induced transcription [PRO-Seq]
PRJNA1108276 | ENA
GenomicsKAP1 negatively regulates elongation kinetics to activate signal-induced transcription [ChIP-Seq]
KAP1 negatively regulates elongation kinetics to activate signal-induced transcription [ChIP-Seq]
PRJNA1108273 | ENA
GenomicsWhole Cell Extract
Most human genes are loaded with promoter proximally paused RNA polymerase II (RNAP II) molecules that are poised for release into productive elongation by P-TEFb. Gdown1, a protein that renders RNAP II responsive to mediator, is involved in RNAP II elongation control. During in vitro transcription ...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-35882 | biostudies-arrayexpress
GenomicsSuper Elongation Complex (SEC) and global genomic analyses in murine embryonic stem (ES) cells and in human cells in response to activation signals.
Transcriptional regulation of developmentally controlled genes is at the heart of differentiation and organogenesis. In this study, we have performed global genomic analyses in murine embryonic stem (ES) cells and in human cells in response to activation signals. We have identified an essential role...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-30267 | biostudies-arrayexpress
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