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ProteomicsInteractome analysis of the Toxoplasma gondii effectors EAF1 and GRA35 by affinity purification and data-independent acquisition mass spectrometry
Toxoplasma gondii is an obligate intracellular parasite that resides within a parasitophorous vacuole and secretes effector proteins that remodel the host cell. This dataset supports a study of the parasite effector EAF1 (TGGT1_225160), investigated as a candidate factor that recruit the host endoso...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii Toxoplasma gondii RH-88 
2026-08-13 | PXD080696 | Pride
Eaf1 Maxlfq Affinity purification mass spectrometry Immunoprecipitation Data-independent acquisition Gra35 Toxoplasma gondii Effector protein Spectronaut Parasitophorous vacuole membrane Host-pathogen interaction Label-free quantification Escrt-i 
UnknownConditional Deletion of Eaf1 Induces Murine Prostatic Intraepithelial Neoplasia in Mice.
Not available
S-EPMC6593215 | biostudies-literature
UnknownELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia.
Not available
S-EPMC153119 | biostudies-literature
UnknownEaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/β-Catenin activity.
Not available
S-EPMC6001683 | biostudies-literature
UnknownZebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance.
Not available
S-EPMC10066051 | biostudies-literature
UnknownZebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression.
Not available
S-EPMC2713535 | biostudies-literature
UnknownATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress.
Not available
S-EPMC9638944 | biostudies-literature
UnknownEaf1 Links the NuA4 Histone Acetyltransferase Complex to Htz1 Incorporation and Regulation of Purine Biosynthesis.
Not available
S-EPMC4452573 | biostudies-literature
ProteomicsAllosteric transcription stimulation by super elongation complex
The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and a subcomplex, ELL2-EAF1, which stimulates transcription elongation by RNA polymerase II (Pol II). Here we report the cryo-EM structure of ELL2-EAF1 bound to a Pol II elongation complex at 2.8 Å re...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2021-07-15 | PXD024457 | Pride
Super elongation complex Stimulation of transcription elongation Transcription Eaf1 P-tefb Pol ii protrusion Rna polymerase ii Ell2 Tfiif 
TranscriptomicsA balancing act: Interactions within NuA4/TIP60 regulate picNuA4 function in Saccharomyces cerevisiae and humans
The NuA4 lysine acetyltransferase complex acetylates histone and non-histone proteins and functions in transcription regulation, cell cycle progression, and DNA repair. NuA4 harbors an interesting duality in that its catalytic module can function independently and distinctly as picNuA4. At the molec...
ORGANISM(S): Saccharomyces cerevisiae 
2022-08-30 | GSE137261 | GEO
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