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TranscriptomicsInterferon Lambda Alleles Predict Innate Antiviral Immune Responses and Hepatitis C Virus Permissiveness.
Hepatitis C virus (HCV) infection can result in viral chronicity or clearance. Although host genetics and particularly genetic variation in the interferon lambda (IFNL) locus are associated with spontaneous HCV clearance and treatment success, the mechanisms guiding these clinical outcomes remain un...
ORGANISM(S): Homo sapiens 
2014-02-12 | E-GEOD-54648 | biostudies-arrayexpress
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsqXL-MS of insulin resistance in C2C12 myotubes
C2C12 myotubes were made insulin resistant with 0.5 mM palmitic acid for 24 h along with non-treated controls and then each group stimulated with or without 100 nM insulin for 30 min (n=4 each). Cells were then cross-linked with 2 mM of tPhoX for a further 30 min in the presence of insulin and the r...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077371 | Pride
Tmt C2c12 Tphox 
TranscriptomicsSilver Nanowire Exposure Results in Internalization and Toxicity to Daphnia magna
Nanowires (NWs), high-aspect-ratio nanomaterials, are increasingly used in technological materials and consumer products and may have toxicological characteristics distinct from nanoparticles. We carried out a comprehensive evaluation of the physicochemical stability of four silver nanowires (AgNWs)...
ORGANISM(S): Daphnia magna 
2013-12-31 | E-GEOD-47064 | biostudies-arrayexpress
ProteomicsHepG2 secretome tagged with the sugar analogs GalNAz and GalNAzMe
Chemically modified analogs of GalNAc, termed GalNAz or GalNAzMe, were incorporated in secreted glycoproteins. The compounds contain bioorthogonal, clickable functional groups that allowed for enrichment using biotin. Chemical glycoproteomics was performed after on-bead digestion and cleavage of gly...
ORGANISM(S): Homo sapiens (Human) 
2020-09-14 | PXD020648 | Pride
Glycosylation Bioorthogonal Mucin Chemical proteomics Enrichment Biotin 
MetabolomicsA general non-self response as part of plant immunity
Plants, like other multicellular lifeforms, are colonized by microorganisms. How plants respond to their microbiota is currently not well understood. We used a phylogenetically diverse set of 39 endogenous bacterial strains from Arabidopsis thaliana leaves to assess host transcriptional and metaboli...
2021-09-13 | MTBLS2522 | MetaboLights
TranscriptomicsCentrosome amplification is sufficient to promote spontaneous tumorigenesis in mammals
Centrosome amplification is a common feature of human tumors, but whether this is a cause or a consequence of human cancer remains unclear. Here, we report the creation of a mouse model in which centrosome number can be persistently increased in the absence of additional genetic defects. We show tha...
ORGANISM(S): Mus musculus 
2017-02-04 | E-MTAB-5043 | biostudies-arrayexpress
MetabolomicsThe genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
Iridoids are non-canonical monoterpenoids produced by both insects and plants. An example is the cat attracting and insect repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable c...
2026-04-20 | MTBLS9357 | MetaboLights
UnknownRationale and design of the HERZCHECK trial: Detection of early heart failure using telemedicine and cardiovascular magnetic resonance in structurally weak regions (NCT05122793).
Not available
S-EPMC11870244 | biostudies-literature
TranscriptomicsResponse of Rhodospirillum rubrum S1H to three pharmaceuticals
The present study explores the potential of compound-specific gene-upregulation profiles in the ubiquitous purple nonsulfur bacterium Rhodospirillum rubrum S1H as biomarkers for exposure to surface water contaminants, i.e. high production-volume pharmaceuticals. Even though the pharmaceuticals [i.e....
ORGANISM(S): Rhodospirillum rubrum 
2013-08-23 | E-GEOD-23794 | biostudies-arrayexpress
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