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Using affinity purification, mass spectrometry, and phospho-enrichment of isotope-labeled peptides, we examined the CD147 microenvironment and CD147-dependent signaling cascades in the Jurkat acute T cell leukemic cell line and its dynamics upon treatment with T cell stimulating agents.
ORGANISM(S): Homo sapiens (Human) 
2017-02-06 | PXD002055 | Pride
The data contains single-cell gene sequencing data (10x Genomics) from FACS-purified CD8 T lymphocytes from two Austrian patients. The cells were stimulated with one MHC class I peptides obtained from a common (wild type) variant and an emerging mutant variant of the SARS-Cov-2 virus. Then the samp...
Full information about the T cell receptor (CR) variable regions found in the sequences of the vdj region. Columns: barcode is_cell contig_id high_confidence length chain v_gene d_gene j_gene c_gene full_length productive cdr3 cdr3_nt reads umis raw_clonotype_id raw_consensus_id
CD8+ T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here, we identified non-synonymous mutations in MHC-I restricted CD8+ T cell epitopes after deep sequencing of 747 SARS-CoV-2 virus isolates. Mutant peptides exhibited diminished or abrogated MHC-I binding...
Data Access Committee EGAC00001001989
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