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ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. A three-phase prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-14 | PXD019945 | Pride
Pbmc Glucocorticoid Proteomics Dexamethasone Biomarker 
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-11 | PXD031622 | Pride
S. aureus secretome Multiomics Actinic keratosis Skin Dna damage Squamous cell carcinoma 
ProteomicsSkin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes
Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...
ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus 
PXD031676 | panorama
UnknownArthroscopically Assisted Acromioclavicular and Coracoclavicular Reconstruction with a Looped Braided Polyester Suture Band and Buckle Device
Not available
S-EPMC9134311 | biostudies-literature
UnknownFirst-in-human, randomized, double-blind, placebo-controlled, dose escalation trial of the anti-herpes simplex virus monoclonal antibody HDIT101 in healthy volunteers.
Not available
S-EPMC9579396 | biostudies-literature
UnknownSetting the basis of best practices and standards for curation and annotation of logical models in biology-highlights of the [BC]2 2019 CoLoMoTo/SysMod Workshop.
Not available
S-EPMC7986594 | biostudies-literature
ProteomicsAntibody-free multiplex measurement of 23 human cytokines in primary cell culture secretome using targeted multiple reaction monitoring mass spectrometry
Cytokines are key mediators of inflammation that commonly serve as biomarkers to monitor immune responses and inflammatory disease. Cytokines are commonly measured by immunoassays, which have limited multiplexing capacity, are costly and can exhibit cross-reactivity. Although multiple reaction monit...
ORGANISM(S): Homo Sapiens 
2020-02-19 | PXD015448 | panorama
ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Context Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. Objective T...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD019972 | panorama
TranscriptomicsGenome-wide expression analysis demonstrates a dominant role of TLR4 for activation of human phagocytes by the alarmin MRP8
The alarmins myeloid-related protein (MRP) 8 and MRP14 are the dominant cytoplasmic proteins in phagocytes. After release by activated phagocytes extracellular MRP8/MRP14 complexes promote inflammation in many diseases, including infections, allergies, autoimmune diseases, rheumatoid arthritis or in...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-56681 | biostudies-arrayexpress
UnknownMaraviroc, as a Switch Option, in HIV-1-infected Individuals With Stable, Well-controlled HIV Replication and R5-tropic Virus on Their First Nucleoside/Nucleotide Reverse Transcriptase Inhibitor Plus Ritonavir-boosted Protease Inhibitor Regimen: Week 48 Results of the Randomized, Multicenter MARCH Study.
Not available
S-EPMC5853584 | biostudies-literature
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