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MetabolomicsDifferential Metabolomic Biomarkers Analysis of Apheresis Platelet Storage Based on Machine Learning Models

Platelet storage lesion (PSL) is a critical factor limiting the efficacy of platelet transfusion. Although hypothermic (4°C) storage is considered beneficial for maintaining platelet function, the underlying mechanisms of systemic metabolic reprogramming remain incompletely understood. This study...

2026-07-27 | MTBLS15165 | MetaboLights
ProteomicsHb Oxidation in stored RBCs and Vesicles
We used a state of the art proteomics workflow, based upon nano-UPLC-MS\MS and advanced database searching to identify oxidative modifications to functional residues of hemoglobin subunit beta . Progressive accumulation of oxidized residues in stored erythrocytes and selective removal in vesicles wa...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-04 | MSV000080222 | MassIVE
TranscriptomicsRainbow trout red blood cells (RBCs): Control vs Heat shock, repeated samples from individuals
The retention of a nucleus in the mature state of fish red blood cells (RBCs), and the ability to easily collect and manipulate blood in non-terminal experiments, makes it an ideal tissue on which to study the cellular stress response in fish. Through the use of the cGRASP 16K salmonid microarray, w...
ORGANISM(S): Oncorhynchus mykiss 
2010-09-21 | E-GEOD-21084 | biostudies-arrayexpress
ProteomicsVESICULATION OF RED BLOOD CELLS IN THE BLOOD BANK: A MULTI-OMICS APPROACH TOWARDS IDENTIFICATION OF CAUSES AND CONSEQUENCES
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions. The triggers and mechanism of microvesicle gener...
ORGANISM(S): Homo sapiens (Human) 
2020-04-03 | PXD017056 | Pride
Metabolomics Blood Lipidomics Proteomics Rbc 
ProteomicsPhosphoproteomics and Morphology of Red Blood Cells treated by Protein-Tyrosine-Phosphatases Inhibitor
Phosphorylation of proteins is involved in cell functions, of which cytoskeleton organization. In particular, the phosphotyrosine (pY) has been reported to play a role in red blood cell (RBC) functions. During the storage of RBC in the context of transfusion medicine, cells suffer from storage lesio...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039914 | Pride
Protein tyrosine phosphorylation Storage of red blood cells Kinase inhibitors Digital holographic microscopy Transfusion medicine. 
UnknownFrequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.
Not available
S-EPMC6347021 | biostudies-literature
ProteomicsPre-transfusion storage alters the proteostasis function and capacity to circulate of a morphologically- and metabolically-altered red cell subpopulation, but preserves other red cells
This study aimed to provide a characterization of morphologically-altered red blood cells (RBCs) and to compare their properties to those of long-stored morphologically normal RBCs and to short-stored RBCs. For proteomics experiments, RBC concentrates stored in blood bank conditions were submitted t...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD049411 | Pride
Proteomics Proteasome activity Red blood cells Red cell storage Lfq Cfse staining Spleen filtration Red cell morphology Proteostasis 
UnknownStorage of packed red blood cells impairs an inherent coagulation property of erythrocytes.
Not available
S-EPMC9732456 | biostudies-literature
TranscriptomicsMicroarray analysis of splenic reservoir monocytes and their blood counterparts
A current paradigm states that monocytes circulate freely and patrol blood vessels, but differentiate irreversibly into dendritic cells or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The re...
ORGANISM(S): Mus musculus 
2009-08-02 | E-GEOD-14850 | biostudies-arrayexpress
UnknownStored red blood cell susceptibility to in vitro transfusion-associated stress conditions is higher after longer storage and increased by storage in saline-adenine-glucose-mannitol compared to AS-1.
Not available
S-EPMC4573361 | biostudies-literature
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