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TranscriptomicsRNA quality and the influence on gene expression
We created RNA with different degree of degradation and investigated if the RNA quality influenced gene expression We used oligo-cDNA-microarrays to compare gene expressions Keywords: RNA quality, breast cancer, gene expression Six breast cancer samples were used, each sample were divided in four an...
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-9219 | biostudies-arrayexpress
GenomicsEvolutionary consequences of DNA methylation on the GC content in vertebrate genomes
The genomes of many vertebrates show a characteristic variation in GC content. To explain its origin and evolution mainly three mechanisms have been proposed, selection for GC content, mutation bias and GC-biased gene conversion. At present the mechanism of GC-biased gene conversion, i.e. short-scal...
ORGANISM(S): Gallus gallus 
2015-01-23 | E-GEOD-56639 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy.
Gene expression profiling of breast tumors for prognosis of local reccurence. Dual channel arrays with a tumor sample in one channel and a common reference in the other channel.
ORGANISM(S): Homo sapiens 
2011-09-02 | E-GEOD-31863 | biostudies-arrayexpress
ProteomicsEffects of recombinant α1-microglobulin on early proteomic response in risk organs after exposure to 177Lu-octreotate
Introduction: Recombinant α1-microglobulin (A1M) is a proposed radioprotector during 177Lu-octreotate treatment of neuroendocrine tumors. Treatment with 177Lu-octreotate is currently limited by bone marrow and renal toxicity. Co-administration of 177Lu-octreotate and A1M could result in a more effec...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD029937 | Pride
Proteomics Radio-protector Lc-ms Kidney 177lu-octreotate Alpha-1-microglobulin 
TranscriptomicsHigh-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer.
Male breast cancer (MBC) is extremely rare and poorly characterized on the molecular level. Using high-resolution genomic data, we aimed to characterize MBC by genomic imbalances and to compare it with female breast cancer (FBC), and further to investigate whether the genomic profiles hold any progn...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-50512 | biostudies-arrayexpress
GenomicsEvolutionary conservation of the eumetazoan gene regulatory landscape
Bilaterian animals differ from other metazoans in their apparent bilateral symmetry and the development of a third germ layer. Both might have facilitated the evolution of the diverse and complex bilaterian body plans. The first cnidarian genome sequence revealed that despite their morphological sim...
ORGANISM(S): Nematostella vectensis 
2013-12-02 | E-GEOD-46488 | biostudies-arrayexpress
TranscriptomicsGenomic Subtypes of Breast Cancer Identified by Array Comparative Genomic Hybridization
Breast cancer is a profoundly heterogeneous disease with respect to biological and clinical behavior. Gene expression profiling has been used to dissect this complexity and stratify tumors into intrinsic gene expression subtypes associated with distinct biology, patient outcome and different genomic...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22133 | biostudies-arrayexpress
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