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ProteomicsProteome Analysis of AAV producing HEK293 cells
Adeno-associated viral (AAV) vectors are widely used for gene therapy, providing treatment for diseases caused by absent or defective genes. Despite the success of gene therapy, AAV-manufacturing is still challenging, with production yields being limited. With increased patient demand, improvements ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-09 | PXD028154 | Pride
Hek293 Proteomics Gene therapy Aav Lc-ms/ms Label free 
ProteomicsmoDCs HPLC-MS/MS - Unbiased Quantitative Proteomics Reveals a Crucial Role of the Allergen Context for the Activation of Human Dendritic Cells
To investigate the allergenicity of the major birch pollen allergen Bet v 1 and the impact of known adjuvants coming from pollen, such as lipopolysaccharide (LPS), we performed quantitative proteome analysis of stimulated monocyte-derived dendritic cells (moDCs). Thus, we treated cells with birch po...
ORGANISM(S): Homo sapiens (Human) 
2017-12-01 | PXD006196 | Pride
Human Modc Hplc-ms/ms 
ProteomicsAnalysis of IgG1 producing CHO cells
The effects of changes in bioprocessing parameters (temp, pH, DO) on anti-IL8 IgG1 producing Chinese hamster ovary (CHO) cells were studied on the level of host cell proteome expression using TMT-SPS-MS3.
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-04-09 | PXD017779 | Pride
Sps-ms3 Tmt Cho 
ProteomicsDIA based HCP detection in protein A purified IgG1
Detection and quantitation of host cell proteins in monoclonal antibody drug products using automated sample preparation and data independent acquisition LC-MS/MS
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-05-26 | PXD020127 | Pride
Data independent acquisition (data independent acquisition (dia) Host cell proteins (hcps) Liquid chromatography mass spectrometry Chinese hamster ovary cells (cho)dia) Critical quality attributes (cqa) Monoclonal antibody (mab) Chinese hamster ovary cells (cho) 
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