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ProteomicsAspartate residues far from the active site drive O-GlcNAc transferase substrate selection
Here we use protein microarray technology and proteome-wide glycosylation profiling to show that conserved aspartate residues in the tetratricopeptide repeat (TPR) lumen of OGT drive substrate selection. Changing these residues to alanines alters substrate selectivity and unexpectedly increases rate...
ORGANISM(S): Homo sapiens (Human) 
2019-07-26 | PXD014731 | Pride
Glycoproteomics O-glcnac 
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
ProteomicsProteomic analysis of healthy human Aqueous Humour, Anterior Lens Capsules, and Crystalline Lenses
Participants were recruited from the Ophthalmology Department among patients scheduled for cataract surgery. Patients were stratified into four distinct groups based on their clinical profiles. ARC group (Age-Related Cataract) included individuals over the age of 75 without a history of diabetes; DC...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD069667 | Pride
Anterior lens Human aqueous humour Capsules Proteomics 
ProteomicsProteomic changes in lens of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045557 | Pride
Cataract Aging Vitrectomy Diabetes Crystallin Cytoskeleton Lens Proteomics 
ProteomicsProteomic changes in anterior capsule of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045547 | Pride
Anterior capsule Cataract Aging Vitrectomy Diabetes Crystallin Cytoskeleton Proteomics 
ProteomicsProteomic changes in aqueous humor of diabetic, age-related and post-vitrectomy cataract.
The focus of our research centers on exploring the proteome changes and corresponding signaling pathways involved in the development of diabetic cataract, age-related cataract and post-vitrectomy cataract, investigating aqueous humor, anterior capsule and lens human samples. Outstanding proteomic pr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045554 | Pride
Keywords cataract Aqueous humor Aging Vitrectomy Diabetes Crystallin Cytoskeleton Proteomics 
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