Sort   by:  
 Page size 
ProteomicsProtein and metabolite composition of the Arabidopsis stress granules.
Stress granules are evolutionary conserved aggregates of proteins and untranslated mRNAs formed in response to stress. Herein, we report protein composition of the Arabidopsis SGs supporting their role in plant response to stress. Moreover, and to our knowledge for the first time, we provide eviden...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-03-27 | PXD010455 | Pride
Ap-ms Stress granules Protein Metabolite Arabidopsis thaliana Lc-ms/ms 
ProteomicsUbiquitination regulates granulostasis and DRiP accumulation in SGs under heat stress via the E3 ligase MKRN2
Stress granules (SGs) are transient cytoplasmic biomolecular condensates that play a role in the cellular response to proteotoxic stress. It has been previously shown that ubiquitination regulates SG dynamics; however, the specific mechanisms by which ubiquitin affects SGs are not fully understood. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD076622 | Pride
Stress granules ubiquitin 
ProteomicsThe Proteome and Transcriptome of Stress Granules and P-Bodies during Human T Lymphocytes Activation
Stress granules (SGs) and processing bodies (PBs) are membraneless cytoplasmic assemblies regulating mRNAs under environmental stress such as viral infections, neurological disorders, or cancer. Upon antigen stimulation, T lymphocytes mediate their immune functions under regulatory mechanisms involv...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD031639 | Pride
Human t lymphocytes Ribonucleoprotein granules Proteome 
MetabolomicsRIOK1 Phase Separation Shapes Stress Adaptation and Cell Fate in Hepatocellular Carcinoma

Cancer cells can always be unexpected rescued from desperate environment by mounting adaptive responses to resolve the arising cellular stress. The dynamic stress granules (SGs) assembly and metabolic reprogramming play crucial roles in maintaining cellular growth and homeostasis. However, the me...

2025-02-26 | MTBLS11963 | MetaboLights
ProteomicsProtein and metabolite composition of Arabidopsis stress granules
• Stress granules (SGs) are evolutionary conserved aggregates of proteins and untranslated mRNAs formed in response to stress. Despite their importance for stress adaptation, no complete proteome composition has been reported for plant SGs. Herein, we addressed the existing gap. Importantly, we also...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-07 | PXD011716 | Pride
Cdka1 Arabidopsis thaliana Stress granules proteome Stress response Stress granule metabolome Affinity purification Stress granule extraction 
ProteomicsDiverse CMT2 neuropathies are linked to aberrant G3BP interactions in stress granules
Complex diseases often involve the interplay between genetic and environmental factors. Charcot-Marie-Tooth type 2 neuropathies (CMT2) are a group of genetically heterogeneous disorders, in which similar peripheral neuropathology is inexplicably caused by various mutated genes. Their possible molecu...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038754 |
ProteomicsThe 19S RP-associated deubiquitylation downstream of AP-3β disassembles heat-induced stress granules in plants
To survive under adverse conditions, plants form stress granules (SGs) to temporally store mRNA and halt translation as a primary response. Dysregulation in SG disassembly can have detrimental effects on plant survival after stress release, yet the underlying mechanism remains poorly understood in p...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-01-24 | PXD054299 | Pride
Stress granules (sgs)  ap-3β  19s rp  deubiquitylation  non-proteolytic function 
ProteomicsFasnall induces atpically transient Stress Granules
Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granules formation, leading to increased cellular fitness and apoptosi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021229 | Pride
Stress granule Fasnall Pabpc1 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-29 | PXD033533 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
ProteomicsNeuromelanin granules of the substantia nigra: proteomic profile provides links to tyrosine hydroxylase, stress granules and lysosomes
Neuromelanin is a black-brownish pigment, present in so-called neuromelanin granules (NMGs) in the cell bodies of dopaminergic neurons in the substantia nigra (SN) pars compacta. These neurons are lost in neurodegenerative diseases like Parkinson’s disease and dementia with Lewy bodies. Although it ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-14 | PXD033381 | Pride
Laser microdissection Stress granules Mass spectrometry Substantia nigra pars compacta Neuromelanin synthesis Neuromelanin granules 
Sort   by:  
 Page size