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TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
TranscriptomicsDynamic mRNA Expression analysis of cells undergoing synchronous life-cycle differentiation in Trypanosoma brucei
mRNA expression profiles of trypanosomes from two discrete bloodstream form stages of the parasite (slender and stumpy forms), as well as during the transition of the stumpy population to the procyclic life-cycle stage were studied. Our analysis represents the first comparison of in vivo derived ple...
ORGANISM(S): Trypanosoma brucei 
2010-05-16 | E-GEOD-17026 | biostudies-arrayexpress
TranscriptomicsRegulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
The gene expression of Trypanosoma brucei has been examined extensively in the blood of mammalian hosts and in forms found in the midgut of its arthropod vector, the tsetse fly. However, trypanosomes also undergo development within the mammalian bloodstream as they progress from morphologically M-bM...
ORGANISM(S): Trypanosoma brucei brucei 
2013-12-16 | E-GEOD-46388 | biostudies-arrayexpress
ProteomicsProteomic analysis of the bloodstream forms (slender, stumpy-QS, stumpy-Glyc, intermediate-Glyc) and procyclic forms of Trypanosoma brucei.
In the mammalian bloodstream, proliferative slender forms of T. brucei differentiate into cell cycle-arrested stumpy forms (stumpy-QS) via a quorum sensing mechanism triggered by high parasite density. This transition is thought to protect the host from excessive parasitaemia while preparing the par...
ORGANISM(S): Trypanosoma brucei 
2026-06-23 | PXD056405 | Pride
Glycerol-induced differentiation Label-free quantitative proteome analysis. Bloodstream forms Trypanosoma brucei Transmission 
UnknownHydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms.
Not available
S-EPMC1748198 | biostudies-literature
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | GSE46483 | GEO
TranscriptomicsDepolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
Trypanosoma brucei are protozoan parasites that cause sleeping sickness in humans and nagana in cattle. Inside the mammalian host, a quorum sensing-like mechanism coordinates its differentiation from a slender replicative form into a quiescent stumpy form, limiting growth and virulence. SUMOylation ...
ORGANISM(S): Trypanosoma brucei 
2024-04-03 | GSE261736 | GEO
ProteomicsExtracellular release of two peptidases dominates generation of the quorum sensing signal in Trypanosoma brucei
Trypanosomes causing African sleeping sickness use quorum sensing to control the production of transmission-competent stumpy forms in their mammalian hosts. This density-dependent process is signalled by the release of parasite peptidases whose action generates oligopeptides that stimulate the signa...
ORGANISM(S): Trypanosoma brucei 
2022-08-12 | PXD032101 | Pride
Stumpy forms Peptidase Trypanosoma brucei Transmission Quorum sensing 
GenomicsDepolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
Depolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites
PRJNA1088517 | ENA
UnknownDepolymerization of SUMO chains induces slender to stumpy differentiation in T. brucei bloodstream parasites.
Not available
S-EPMC11060531 | biostudies-literature
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