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TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 (Illumina smRNA-Seq]
Salivary glands or larval ovaries were isolated from transgenic flies expressing RNAi targeting Nautilus (control) or linker histone H1 using a Tub-Gal4 driver. ~200 larvae were used to isolate salivary glands or ovaries, independently. Total RNA was isolated using Trizol reagent following manufact...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44399 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1 [Affymetrix Expression]
Indicated cells were subjected to RNAi against linker histone H1, Nautilus (control), or GFP (control). RNA was isolated and subjected to Affymetrix GeneChIP Drosophila Genome 2.0 arrays RNA was compared from cells treated with RNAi against control (Nautilus in the case of salivary glands or GFP in...
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44398 | biostudies-arrayexpress
TranscriptomicsAnalysis of Drosophila salivary glands and Kc cells with depleted levels of linker histone H1
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2013-04-22 | E-GEOD-44148 | biostudies-arrayexpress
UnknownBrainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery.
Not available
S-EPMC6026028 | biostudies-literature
ProteomicsCSF1R-CAR T cells induce CSF1R signaling and promote target cell growth
Chimeric antigen receptor (CAR) T cells have revolutionized the landscape of cancer therapy, demonstrating unprecedented success in treating relapsed or refractory blood cancers. Previous studies of the mechanisms underlying the interactions and responses of CAR T cells and their targets have focuse...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD058576 | Pride
ProteomicsPhosphoproteomic analysis of successive Jurkat CD19-CAR generations reveals TCRζ-driven signalling
Although chimeric antigen receptor (CAR) T cell therapy has revolutionised individualised cancer therapies for relapsed/refractory lymphomas, low long-term retention due to basal signalling (antigen-independent activation in the absence of cognate antigen) and off-target toxicity limit the broad app...
ORGANISM(S): Homo sapiens (Human) 
2025-11-21 | PXD065669 | Pride
ProteomicsCAR T cells inhibit B cell activating phosphorylation in their targets
Adoptive cell therapy, a subset of cancer immunotherapy, is collection of therapeutic approaches which aim to redirect the immune system by reprogramming patient T-cells to target antigenic molecules differentially and specifically expressed in certain cancers. One promising immunotherapy technique ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-28 | PXD028109 | Pride
Cart signaling Phosphoproteomics Phosphotyrosine 
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
GenomicsGenome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with ge...
ORGANISM(S): Mus musculus 
2011-06-23 | E-GEOD-21950 | biostudies-arrayexpress
GenomicsSuper-Enhancer-mediated Control of Liver Fibrosis by BET Bromodomain Proteins
Here, we investigate the role of enhancers in myofibroblasts, a cell type that dominates the pathogenesis and progression of tissue fibrosis. We reveal that bromodomain and extra-terminal family members (BETs), an important group of epigenetic readers, are critical for super-enhancer-mediated pro-fi...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-58680 | biostudies-arrayexpress
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