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MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
GenomicsSubcellular location defines GPCR signal transduction
Subcellular location defines GPCR signal transduction
PRJNA915973 | ENA
ProteomicsSubcellular location defines GPCR signal transduction
G protein-coupled receptors in intracellular organelles can be activated in response to membrane permeant ligands, which contributes to the diversity and specificity of agonist action. The opioid receptors (ORs) provide a striking example, where small molecule opioid drugs activate ORs in the Golgi ...
ORGANISM(S): Homo sapiens (Human) 
2023-04-25 | PXD038921 | Pride
Phosphoproteomics Snc80 Golgi Hek293 Opioid Dor Gpcr Lc-esi-ms/ms 
OtherA Comprehensive Subcellular Proteomic Survey of Salmonella Grown under Phagosome-Mimicking versus Standard Laboratory Conditions.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00551 PASS00551]]. File: SBEP_STM_subcell-53c_14Jan11_Doc_10-09-53.mzml. Published as part of . From the Abstract: {{i}} Towards developing a systems-level pathobiological understanding of Salmonella enterica, we performed a subcellular...
ORGANISM(S): Salmonella_phage_c341_uid39795,salmonella_phage_e1_uid29079,salmonella_phage_epsilon34_uid33779,salmonella_phage_fels_1_uid29267,salmonella_phage_phisg_jl2_uid30063,salmonella_phage_se1_uid33483,salmonella_phage_setp3_uid19157,salmonella_phage_st64b_uid14228, Salmonella_enterica_serovar_typhimurium_14028s 
GPM32310003265 | GPMDB
ProteomicsSubcellular proteomic survey of Salmonella
The project performed a subcellular proteomic analysis of Salmonella enterica subsp. enterica serovar Typhimurium str. 14028 grown under standard laboratory and phagosome-mimicking conditions in vitro. Analysis of proteins from cytoplasmic, inner membrane, periplasmic, and outer membrane fractions y...
ORGANISM(S): Salmonella typhimurium (strain 14028s / SGSC 2262) 
2013-10-07 | PXD000388 | Pride
Localization Subcellular Cytoplasmic Outer membrane Inner membrane Periplasmic 
GenomicsAltered Subcellular Localization of Transcription Factor TEAD4 Regulates First Mammalian Cell Lineage Commitment
In the preimplantation mouse embryo TEAD4 is critical to establishing the trophectoderm (TE)-specific transcriptional program and segregating TE from the inner cell mass (ICM). However, TEAD4 is expressed both in the TE and the ICM. Thus, differential function of TEAD4 rather than expression itself ...
ORGANISM(S): Mus musculus 
2012-04-18 | E-GEOD-37350 | biostudies-arrayexpress
UnknownConsistency and variation of protein subcellular location annotations.
Not available
S-EPMC7790864 | biostudies-literature
TranscriptomicsSubcellular location defines GPCR signal transduction
G protein-coupled receptors in intracellular organelles can be activated in response to membrane permeant ligands, which contributes to the diversity and specificity of agonist action. The opioid receptors (ORs) provide a striking example, where small molecule opioid drugs activate ORs in the Golgi ...
ORGANISM(S): Homo sapiens 
2023-04-24 | GSE221762 | GEO
TranscriptomicsRole of Aldoketoreductases and Other Doxorubicin Pharmacokinetic Genes in Doxorubicin Resistance, DNA binding, and Subcellular Localization
Objective: To assess the role of aldoketoreductases and other doxorubicin pharmacokinetic or pharmacogenomic genes in doxorubicin cytotoxicity, resistance, DNA binding activity, and subcellular localization, Methods: We conducted a whole genome microarray study to identify differences in betwee...
ORGANISM(S): Homo sapiens 
2012-11-22 | E-GEOD-27254 | biostudies-arrayexpress
ProteomicsSimultaneous proteome localization and turnover analysis reveals spatiotemporal coordinations of unfolded protein response
The functionality of proteins is dependent on their spatial and temporal distributions, neither of which is directly measured by static protein abundance. Here we report a mass spectrometry-based proteomics workflow and data analysis pipeline, named Simultaneous Proteome Localization and Turnover (...
ORGANISM(S): Homo Sapiens (human) 
2022-12-31 | PXD038054 | JPOST Repository
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