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ProteomicsThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3
The subcortical maternal complex (SCMC) is essential for the maintenance of female fertility in mammals. Most pathogenic mutations in SCMC-encoding genes result in female reproductive failure characterized by early embryonic arrest. Assembled in oocytes, the SCMC maintains the normal cleavage of ear...
ORGANISM(S): Mus Musculus Spodoptera Frugiperda 
PXD055498 |
UnknownA subcortical maternal complex essential for preimplantation mouse embryogenesis.
Not available
S-EPMC2597058 | biostudies-literature
GenomicsNovel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith-Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances
Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith-Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances
PRJNA802536 | ENA
ProteomicsAn Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by significant reduction in DNMT3L
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorde...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD056859 | Pride
Nlrp5 Subcortical maternal complex Oocyte Dna methylation 
UnknownTwo Novel Protein-Truncating Variants in NLRP2 and Their Functional Impacts on the Subcortical Maternal Complex.
Not available
S-EPMC12215214 | biostudies-literature
UnknownMaternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming.
Not available
S-EPMC5357799 | biostudies-literature
UnknownThe subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.
Not available
S-EPMC6529946 | biostudies-literature
ProteomicsComparative maternal protein profiling of mouse biparental and uniparental embryos
During oogenesis, RNAs and proteins from maternal genome will be accumulated and they are the most important regulatory factors in early embryonic development. Parthenogenesis provides a unique source to investigate the influence of maternal genomes in early mammalian development and is proposed as ...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD029532 |
UnknownThe subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3.
Not available
S-EPMC11480350 | biostudies-literature
UnknownSubcortical maternal complex (SCMC) expression during folliculogenesis is affected by oocyte donor age in sheep.
Not available
S-EPMC7492316 | biostudies-literature
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