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MetabolomicsElucidation of the epitranscriptomic RNA modification landscape of chikungunya virus

The genomes of positive-sense (+) single-stranded RNA (ssRNA) viruses are believed to be subjected to a wide range of RNA modifications. In this study, we focused on the chikungunya virus (CHIKV) as a model (+) ssRNA virus to study the landscape of viral RNA modification in infected human cells. ...

2024-06-11 | MTBLS8697 | MetaboLights
ProteomicsUCHL3 regulates subgenomic flaviviral RNA condensates to promote virus propagation
Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organised and maintained in cells remains poorly understood. Here we identify ubiquitin C-terminal hydrolase L3 (UCHL3) as a post-translational regulator of flavivirus sfRNA stability and function. Using a proximit...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075983 | Pride
Dengue virus Flavivirus Biomolecular condensates Uchl3 Sfrna Zika virus Subgenomic rna 
ProteomicsIdentification of proteins differentially associated with SARS CoV-2 subgenomic RNAs
We characterize the specific protein interactomes of 3 SARS sgRNAs (S, N, and ORF8) as well as the gRNA at two time points, 8- and 24- hours. These two timepoints were selected to capture early viral infection when RNA synthesis is just beginning, and viral replication is being established, as well ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-30 | PXD040147 | Pride
Viral Proteomics S rna Mass spectrometry N rna Rna-protein interactions Rna metabolism Grna Interactome Sars cov-2 Hybridization Orf8 rna Rna binding proteins 
ProteomicsIDRE (Interaction Dengue RNA and Extracellular vesicles)
The project aims to identify the proteins capable of interacting with a part of the genomic RNA of the dengue virus, the flaviviral subgenomic RNA. Our team has discovered the presence of this RNA in mosquito vesicles, and the goal is to identify how the flaviviral subgenomic RNA of the dengue virus...
ORGANISM(S): Aedes aegypti 
2026-03-01 | PXD065152 | Pride
Supernatant Cell Mosquito Protein-rna interaction Extracellular vesicles 
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
UnknownSubgenomic promoter recognition by the norovirus RNA-dependent RNA polymerases.
Not available
S-EPMC4288183 | biostudies-literature
ProteomicsSND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9
Regulation of viral RNA biogenesis is fundamental to productive SARS-CoV-2 infection. To characterize host RNA-binding proteins (RBPs) involved in this process, we biochemically identified proteins bound to genomic and subgenomic SARS-CoV-2 RNAs. We find that the host protein SND1 binds the 5ʹ end o...
ORGANISM(S): Homo sapiens (Human) 
2023-10-05 | PXD037528 | Pride
Sars-cov-2 Rna-binding proteins Rna interactome 
UnknownA positive-strand RNA virus with three very different subgenomic RNA promoters.
Not available
S-EPMC112095 | biostudies-literature
UnknownSARS-CoV-2 Total and Subgenomic RNA Viral Load in Hospitalized Patients.
Not available
S-EPMC7941648 | biostudies-literature
UnknownIdentification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA Transcription.
Not available
S-EPMC5941075 | biostudies-literature
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