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GenomicsCut&Run SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
Cut&Run SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
PRJNA915081 | ENA
GenomicsMARS-seq on SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
MARS-seq on SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
PRJNA915084 | ENA
GenomicsSulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo
Sulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo
PRJNA701956 | ENA
ProteomicsCovalent inhibition of the peptidyl-prolyl isomerase Pin1 by Sulfopin results in a broad impact on the phosphoproteome of human osteosarcoma U2-OS cells
Peptidyl-prolyl isomerase, NIMA-interacting protein 1 (Pin1) catalyzes the cis-trans interconversion of the inflexible bond between serine or threonine residues and proline at the +1 position (pSer/pThr-Pro). While initially discovered as an essential regulator of cell division, Pin1 has since been...
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD049431 | Pride
Sgc-ck2-1 Csnk2 Proteomics Pin1 Casein kinase ii Silac Sulfopin Protein kinase ck2 Phosphoproteomics Peptidyl-prolyl cis-trans isomerase nima-interacting 1 
UnknownSulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Not available
S-EPMC9119696 | biostudies-literature
TranscriptomicsSulfopin, a covalent inhibitor of Pin1, blocks Myc-driven tumors in vivo
The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors. However, despite considerable efforts, Pin1 has remained an elusive drug target. Here, we screened an electrophilic fragment library to identify covalent inhibitors targeting Pin1’s ac...
ORGANISM(S): Homo sapiens 
2021-04-01 | GSE166786 | GEO
GenomicsEffect of Sulfopin and Abemaciclib treatment on gene expression in mouse TNBC
Effect of Sulfopin and Abemaciclib treatment on gene expression in mouse TNBC
PRJNA971963 | ENA
GenomicsCut&Run SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
Diffuse midline gliomas (DMG) are aggressive pediatric tumors of the central nervous system that are highly resistant to treatments and are inevitably fatal. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, reshaping the epigenetic landscape of th...
ORGANISM(S): Homo sapiens 
2024-06-24 | GSE221611 | GEO
TranscriptomicsMARS-seq on SU-DIPG13 cells treated Sulfopin/Vorinostat/Sulfopin+Vorinostat or DMSO
Diffuse midline gliomas (DMG) are aggressive pediatric tumors of the central nervous system that are highly resistant to treatments and are inevitably fatal. Lysine to methionine substitution of residue 27 on histone H3 (H3-K27M) is a driver mutation in DMGs, reshaping the epigenetic landscape of th...
ORGANISM(S): Homo sapiens 
2024-06-24 | GSE221612 | GEO
TranscriptomicsEffect of Sulfopin and Abemaciclib treatment on gene expression in mouse TNBC
To investigate the role of combined PIN1 and CDK4 inhibition in the regulation of immune response, we performed RNA sequencing of TNBC tumors after treatment with Sulfopin, Abemaciclib or their combination
ORGANISM(S): Mus musculus 
2024-03-08 | GSE232422 | GEO
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