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ProteomicsA proteomic approach to identify alterations in the SUMO network during controlled mechanical ventilation in rat diaphragm muscle
SUMOylation is a key post-translational modification that regulates crucial cellular functions and pathological processes. It has emerged as a fundamental route that may drive different steps of human diseases. Indeed, alteration in expression or activity of one of the different SUMO pathway compone...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-05 | PXD006085 | Pride
Mechanical ventilation Sumo Sumo biomarkers Diaphragm Skeletal muscle 
ProteomicsProteome-wide identification of SUMO2 modification sites
Posttranslational modification with small ubiquitin-like modifiers (SUMOs) alters the function of proteins involved in diverse cellular processes. SUMOs are conjugated to lysine residues in target proteins by SUMO-specific enzymes. Although proteomic studies have identified hundreds of sumoylated su...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080741 | MassIVE
UnknownA novel role for the SUMO E3 ligase PIAS1 in cancer metastasis.
Not available
S-EPMC4278292 | biostudies-literature
UnknownA cellular and bioinformatics analysis of the SENP1 SUMO isopeptidase in pancreatic cancer.
Not available
S-EPMC6776818 | biostudies-literature
UnknownA Proteomic Approach to Identify Alterations in the Small Ubiquitin-like Modifier (SUMO) Network during Controlled Mechanical Ventilation in Rat Diaphragm Muscle.
Not available
S-EPMC5461539 | biostudies-literature
UnknownDysregulated gene expression of SUMO machinery components induces the resistance to anti-PD-1 immunotherapy in lung cancer by upregulating the death of peripheral blood lymphocytes.
Not available
S-EPMC11357960 | biostudies-literature
ProteomicsGenetic and proteomic screens reveal perturbed nucleotide metabolism and DNA-protein crosslink formation as central mediators of decitabine cytotoxicity
Decitabine (5-aza-dC) is a DNMT1-DPC inducing agent used to treat several hematological cancers. However, response rates vary, relapse is common, and predictive biomarkers are unknown. Here, we develop an adaptation of identification of proteins on nascent DNA (iPOND) by combining EdU with 5-aza-dC ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD045071 | Pride
Decitabine Dna-protein crosslink Topors Global-genome dpc repair Dna methylation Sumo Dnmt1 
GenomicsLufenuron exposure temporarily repress gene expression and the SUMO pathway in liver of Atlantic salmon
Lufenuron exposure temporarily repress gene expression and the SUMO pathway in liver of Atlantic salmon
PRJNA819484 | ENA
UnknownThe working mechanism of biomarkers related to sumoylation modification in coronary artery disease.
Not available
S-EPMC12084532 | biostudies-literature
UnknownStrategies to Identify Recognition Signals and Targets of SUMOylation.
Not available
S-EPMC3395311 | biostudies-literature
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