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TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation 3
mRNA profiling of WI38 expressing shCt or shUbc9 4 days post-infection. The goals of this study is to analyse transcriptionnal changes in cells were sumoylation pathway is inactivated and to compare them with ChIPseq data for several histones marks and proteins of the SUMO machinery.
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3778 | biostudies-arrayexpress
TranscriptomicsRNA-seq of MYC-Low and MYC-High FC-MYC Cells Following SUMOylation Inhibition with SAEi ML-792
The synthetic lethal relationship between MYC and SAE2 has been previously described in FC-MYC cells using RNAi (Littler et al., 2019). Building on this work, we conducted transcriptomic analysis on MYC-low and MYC-high cells following inhibition of SUMOylation with the SAE1/2 inhibitor, ML-792 (SAE...
ORGANISM(S): Homo sapiens 
2025-04-01 | E-MTAB-14654 | biostudies-arrayexpress
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation
mRNA profiling of WI38 wild-type or overexpressiong the SUMO E3 ligase PIASy in human primary fibroblasts 24h post-infection. The goal of this study is to analyse transcriptional changes in cells over-expressing the SUMO E3 ligase PIASy and to compare them with ChIPseq data for several histones mark...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3776 | biostudies-arrayexpress
TranscriptomicsInfluence of SUMOylation on transcriptional signature of hIPSCs (ChiPS4) assessed by time-resolved RNA-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9962 | biostudies-arrayexpress
TranscriptomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-14761 | biostudies-arrayexpress
TranscriptomicsSumoylation at Chromatin Governs Coordinated Repression of a Transcriptionnal Program Essential for Cell Growth and Proliferation 2
mRNA profiling of proliferative versus Ras-induced senescent human primary fibroblasts 5 days post-infection. The goals of this study is to analyse transcriptional changes in senescent cells (RASv12 infected cells)
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MEXP-3777 | biostudies-arrayexpress
TranscriptomicsInfluence of SUMOylation on chromatin structure in hIPSCs (ChiPS4) assessed by time-resolved ATAC-seq in response to ML792 treatment
SUMOylation is thought to regulate chromatin structure and accessibility thus affecting gene expression. In order to assess these potential roles of SUMOylation in human pluripotent stem cells, ChiPS4 cells were treated with ML792 (selective SUMO E1 inhibitor) or DMSO (vehicle control) for the follo...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9961 | biostudies-arrayexpress
GenomicsLandscape of protein SUMOylation on chromatin in hIPSCs (ChiPS4) by SUMO1 CHIP-seq
SUMO1 CHIP-seq experiment was performed in untreated hiPSC line - ChiPS4, to determine the exact locations of chromatin bound SUMO1 in these cells, thus providing information about the landscape of SUMOylation of protein targets on chromatin in human pluripotent cells and as such allowing for invest...
ORGANISM(S): Homo sapiens 
2022-12-01 | E-MTAB-9960 | biostudies-arrayexpress
ProteomicsA short SUMOylation tag modulates transcription factor activity
This research demonstrates that a short peptide, composed of residues 24-55 of ZNF451, is sufficient to induce SUMOylation of target proteins, both in vitro and in human cells. Increased SUMOylation of the transcription factor p53 via fusion with the ZNF451 peptide inhibits its transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD068083 | Pride
Sumo e3 ligase Small ubiquitin-like modifier (sumo) Transcription factor Sumoylation tag Znf451 Sumoylation P53 
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