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ProteomicsNLRP6 controls PTEN stability by promoting autophagic degradation of p85α to drive tumorigenesis
To identify NLRP6-associated proteins in living cells, we applied an APEX2-based labelling method combined with mass spectrometry. In brief, APEX2 was genetically fused to NLRP6. In the presence of hydrogen peroxide, APEX2 catalysed biotin-phenol to become a biotin-phenol radical that covalently bou...
ORGANISM(S): Homo sapiens (Human) 
2023-07-02 | PXD037460 | Pride
Human Lc-ms/ms 
ProteomicsMatrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3
Cartilage aging is a quintessential feature of knee osteoarthritis, and extracellular matrix (ECM) stiffening is a typical feature of cartilage aging. However, the mechanism of ECM stiffening to influence chondrocytes and downstream molecules is still poorly understood. Here, we mimicked the physiol...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-06-16 | PXD046993 | Pride
Cartilago articularis，matrix stiffness，osteoarthritis 
MetabolomicsLinking soil biology and chemistry in biological soil crust using isolate exometabolomics
Metagenomic sequencing provides a window into microbial community structure and metabolic potential; however, linking these data to exogenous metabolites that microorganisms process and produce (the exometabolome) remains challenging. Previously, we observed strong exometabolite niche partitioning a...
2018-07-31 | MTBLS492 | MetaboLights
ProteomicsMetaproteomics of Jiuqu starter and fermented grains
To study the characteristics of proteins in Chinese Chixiang-flavor Baijiu fermentation, a label-free quantitative proteomics approach was established to identify proteins in Jiuqu starter and fermented grains.
ORGANISM(S): Fungi Rhizopus Microsporus Bacteria Lactobacillus Helveticus Cirm-bia 103 Saccharomyces Cerevisiae 
2019-06-11 | PXD014221 |
ProteomicsProteomic studies of the mechanism of cytotoxicity, induced by palytoxin on HaCaT cells
Palytoxin (PLTX) is a polyether Marine toxin isolated from sea anemones. It is one of the most toxic non-protein substances, causing many people to be poisoned every year and die in severe cases. With its known impact on Na+, K+-ATPase, much still remain unclear about the mechanism of PLTX action. H...
ORGANISM(S): Homo Sapiens 
2022-03-24 | PXD032777 |
ProteomicsMetaproteomics of Jiuqu starter
Chinese starter Jiuqu, traditionally produced by spontaneous fermentation and always squeezed into bricks, serves as a vital saccharifying agent for simultaneous saccharification and fermentation of Chinese Baijiu. It is important to reveal the key saccharifying microbiota and the driving force to i...
ORGANISM(S): Rhizopus Microsporus Fungi Lactobacillus Plantarum Subsp. Plantarum Nc8 Bacteria Saccharomyces Cerevisiae 
2018-06-08 | PXD017753 |
ProteomicsA Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
A Multi-omics Comparison Unveils Convergent and Divergent Antidepressant Mechanisms of Fluoxetine and St. John's Wort extract
ORGANISM(S): Mus Musculus 
2025-08-25 | PXD067684 |
UnknownA self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models.
Not available
S-EPMC8721936 | biostudies-literature
ProteomicsAnalysis of Nucleocytoplasmic Protein Separation in DPST-Crosslinked Human Neuroblastoma SY5Y Cells
Following DPST crosslinking of human neuroblastoma cells, nuclear-cytoplasmic fractionation was performed using hypotonic lysis to obtain cytoplasmic and nuclear protein compartments. Through systematic analysis of crosslinking mass spectrometry data, we elucidated how subcellular compartmentalized ...
ORGANISM(S): Homo Sapiens 
2025-04-14 | PXD062913 |
UnknownSyndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Not available
S-EPMC8857282 | biostudies-literature
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