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ProteomicsQuantitative Analysis of Global Proteome in Arabidopsis thaliana
In total, 5,840 protein groups were identified, among which 5,188 proteins were quantified. The fold-change cutoff was set when proteins with quantitative ratios above 1.5 or below 0.667 are deemed significant. Among the quantified proteins, 95 proteins are up-regulated and 155 proteins are down-reg...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-11-12 | PXD011814 | Pride
Arabidopsis thaliana Seedling Lc-ms/ms 
UnknownRandomized controlled trial of icodextrin versus glucose containing peritoneal dialysis fluid.
Not available
S-EPMC2774964 | biostudies-literature
ProteomicsTumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks Nuclear Factor-κB activation in hepatocellular carcinoma
Background: Tumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently downregulated in cancer cell lines and promotes cancer cell apoptosis. However, its role, clinical significance and molecular mechanisms in hepatocellular carcinoma (HCC) are unknown. Methods: The expression of TNFAIP1 in...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD016378 | Pride
Protein kinase casein kinase ii beta Hepatocellular carcinoma Nuclear factor-κb Tumor suppressor Tumor necrosis factor α-induced protein 1 
MetabolomicsBacillus subtilis inhibits African swine fever virus infection in vivo and in vitro based on its metabolites arctiin and genistein interfering with the function of viral topoisomerase II

African swine fever virus (ASFV) is an infectious disease with a mortality rate of nearly 100% in pigs; however, no safe commercial vaccines or antiviral drugs are currently available, which seriously threatens the global pig industry. Therefore, effective biologicals against ASFV are urgently ne...

2023-11-01 | MTBLS6586 | MetaboLights
ProteomicsSuppression of mosquito Aedes aegypti population using a CRISPR-targeted leucine aminopeptidase 1 mutation
Aedes aegypti are vectors of several devastating arboviruses infecting hundreds of millions of people annually. Controlling mosquito populations by regulating their reproduction is important to minimize viral transmission in the absence of effective antiviral therapies or vaccines. Here, we demonstr...
ORGANISM(S): Aedes Aegypti 
2023-02-05 | PXD039869 |
ProteomicsS6K1-mediated phosphorylation of PDK1 impairs AKT kinase activity and oncogenic functions
Functioning as a master kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1) plays a fundamental role in phosphorylating and activating protein kinases A, B and C (AGC) family kinases, including AKT. However, upstream regulation of PDK1 remains largely elusive. Here we report that ribosomal ...
ORGANISM(S): Homo Sapiens 
PXD028167 |
ProteomicsOTU7B modulates the mosquito immune response to Beauveria bassiana infection via deubiquitination of the Toll adaptor TRAF4
Insects use innate immunity to defend microbial infection. Toll pathway is a major immune signaling pathway that is associated with antifungal immune response in mosquitoes. Our study identified a fungal-induced deubiquitinase, OTU7B, which, when knocked out, promotes the translocation of the NF-κB ...
ORGANISM(S): Aedes Aegypti 
2022-11-22 | PXD038261 |
ProteomicsProteomics of male reproduction
To investigate the important function of membrane protein TMEM225 in sperm, we constructed Tmem225 knockout mice. Sperm from knockout mice and control mice were isolated for proteomic analysis.
ORGANISM(S): Mus Musculus 
2024-01-18 | PXD046484 |
ProteomicsLabel-free proteomic analysis of apoptotic, necrotic and necroptotic DAMPs from HNSCC cells
Necroptosis is a newly discovered form of programmed cell death (PCD) showing necrotic features, including membrane permeabilization and the release of damage-associated molecular patterns (DAMPs). Studies have revealed both its tumorigenic role and therapeutic potential in various cancers, yet its ...
ORGANISM(S): Homo Sapiens 
PXD035379 |
ProteomicsGeneration of multi-disease spectral library
We created a multi-disease spectral library using 100 serum samples obtained from five patient groups, including healthy controls (n=20), Bechet's disease (n=20), non-small cell lung cancer (n=20) and liver diseases (n=20). The multi-disease spectral library included a total of 9,104 precursors and...
ORGANISM(S): Homo Sapiens 
2023-03-06 | PXD040603 |
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